An interspecific linkage map of mouse chromosome 15 positioned with respect to the centromere

Camilynn I. Brannan, Debra J. Gilbert, Jeffrey D. Ceci, Yoichi Matsuda, Verne M. Chapman, John A. Mercer, Harvey Eisen, Laura A. Johnston, Neal G. Copeland, Nancy A. Jenkins

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

We have used an interspecific backcross between C57BL 6J and Mus spretus to derive a molecular genetic linkage map of chromosome 15 that includes 25 molecular markers and spans 93% of the estimated length of chromosome 15. Using a second interspecific backcross that was analyzed with a centromere-specific marker, we were also able to position our map with respect to the chromosome 15 centromere. This map provides molecular access to many discrete regions on chromosome 15, thus providing a framework for establishing relationships between cloned DNA markers and known mouse mutations and for identifying homologous genes in mice and humans that may be involved in disease.

Original languageEnglish (US)
Pages (from-to)1075-1081
Number of pages7
JournalGenomics
Volume13
Issue number4
DOIs
StatePublished - Aug 1992

ASJC Scopus subject areas

  • Genetics

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