Abstract
Mycobacterium tuberculosis is a global health concern, causing over one million deaths a year. Alveolar macrophages, as the primary host cell of this intracellular bacterium, play an important role in the course of disease. Vitamin D3 is known to have a potent effect on macrophage behavior during infection, modulating the production of pro- and anti-inflammatory cytokines and immune effector molecules. In a vitamin D3 deficient host, the immune systems response to infection is greatly impaired. We used a quantitative systems biology approach to model the intracellular effects of vitamin D3 and compared our simulation output to our in vitro model of mycobacterium infection of macrophages in the presence and absence of Vitamin D3. Our in silico model results agreed with the in vitro assay results of interleukin-10, an anti-inflammatory protein whose production is known to be influenced by vitamin D3. This model will provide a platform for further investigation of the effects of vitamin D3 deficiency on host immune response to infection.
Original language | English (US) |
---|---|
Title of host publication | 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016 |
Publisher | Institute of Electrical and Electronics Engineers Inc. |
Pages | 1443-1446 |
Number of pages | 4 |
Volume | 2016-October |
ISBN (Electronic) | 9781457702204 |
DOIs | |
State | Published - Oct 13 2016 |
Event | 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016 - Orlando, United States Duration: Aug 16 2016 → Aug 20 2016 |
Other
Other | 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016 |
---|---|
Country/Territory | United States |
City | Orlando |
Period | 8/16/16 → 8/20/16 |
ASJC Scopus subject areas
- Signal Processing
- Biomedical Engineering
- Computer Vision and Pattern Recognition
- Health Informatics