AN IMPROVED NANOVECTOR BASED DRUG DELIVERY SYSTEM FOR OVERCOMING DRUG RESISTANCE

S Baskin, David (Inventor), Daniela Marcano, (Inventor), A Sharpe, Martyn (Inventor), M Tour, James (Inventor)

Research output: Patent

Abstract

Various embodiments of the present invention provide therapeutic compositions for specifically targeting tumor cells. In some embodiments, the therapeutic compositions generally include: (1) a plurality of nanovectors; (2) one or more active agents associated with the nanovectors, where the one or more active agents have activity against the tumor cells; (3) one or more active agent enhancers associated with the nanovectors; and (4) one or more targeting agents associated with the nanovectors, where the one or more targeting agents have recognition activity for one or more markers of the tumor cells. Additional embodiments of the present invention pertain to methods of targeting tumor cells in a subject by administering one or more of the aforementioned therapeutic compositions to the subject. Further embodiments of the present invention pertain to methods of formulating the aforementioned therapeutic compositions for targeting tumor cells in a subject in a personalized manner.

Original languageEnglish (US)
Patent numberCA2912975
IPCA61K 31/ 445 A I
Priority date3/15/13
StatePublished - Apr 24 2014
Externally publishedYes

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