An image driven systems biology approach for neurodegenerative disease studies in the TSC-mTOR pathway

Dominik Beck, Xiaobo Zhou, Tuan Pham, Bernardo Sabatini, Stephen T.C. Wong

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this brief paper we present an overview of the TSC-mTOR pathway and its importance in neurodegenerative disease (ND). We illustrate the influence of ND on dendritic spine morphology. Then we discuss some details of functional gene networks (FGN) and use this information to propose an image driven systems biology approach for the construction of a FGN for ND. We conclude on its importance and the prospective outcome of our study.

Original languageEnglish (US)
Title of host publication2009 IEEE/NIH Life Science Systems and Applications Workshop, LiSSA 2009
Pages36-39
Number of pages4
DOIs
StatePublished - 2009
Event2009 IEEE/NIH Life Science Systems and Applications Workshop, LiSSA 2009 - Bethesda, MD, United States
Duration: Apr 9 2009Apr 10 2009

Publication series

Name2009 IEEE/NIH Life Science Systems and Applications Workshop, LiSSA 2009

Other

Other2009 IEEE/NIH Life Science Systems and Applications Workshop, LiSSA 2009
CountryUnited States
CityBethesda, MD
Period4/9/094/10/09

ASJC Scopus subject areas

  • Computational Theory and Mathematics
  • Biomedical Engineering
  • Electrical and Electronic Engineering

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