An image based system biology approach for Alzheimer's disease pathway analysis

Yue Huang, Xiaobo Zhou, Benchun Miao, Marta Lipinski, Zheng Xia, Guangshu Hu, Alexei Degterev, Junying Yuan, Stephen T.C. Wong

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Scopus citations

Abstract

We report multifactorial analysis of candidate mechanisms of Alzheimer's disease utilizing high content analysis, gene expression microarray, and linear regression model to integrate neuronal imaging data with hippocampal gene expression data. Our analysis led to the identification of several genes that may contribute to different image traits or phenotypes in the amyloid-beta (Aβ) injured neurons. Gene network and biological pathways analysis for those genes were further analyzed and led to several novel pathways that may contribute to amyloid plaque triggered neurite loss.

Original languageEnglish (US)
Title of host publication2009 IEEE/NIH Life Science Systems and Applications Workshop, LiSSA 2009
Pages128-132
Number of pages5
DOIs
StatePublished - 2009
Event2009 IEEE/NIH Life Science Systems and Applications Workshop, LiSSA 2009 - Bethesda, MD, United States
Duration: Apr 9 2009Apr 10 2009

Publication series

Name2009 IEEE/NIH Life Science Systems and Applications Workshop, LiSSA 2009

Other

Other2009 IEEE/NIH Life Science Systems and Applications Workshop, LiSSA 2009
CountryUnited States
CityBethesda, MD
Period4/9/094/10/09

ASJC Scopus subject areas

  • Computational Theory and Mathematics
  • Biomedical Engineering
  • Electrical and Electronic Engineering

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