An Id-related helix-loop-helix protein encoded by a growth factor-inducible gene

Barbara A. Christy, Laura K. Sanders, Lester F. Lau, Neal G. Copeland, Nancy A. Jenkins, Daniel Nathans

Research output: Contribution to journalArticle

298 Scopus citations

Abstract

An mRNA encoding a helix-loop-helix protein that we have named HLH462 is induced in mouse 3T3 cells as part of the immediate early transcriptional response to growth factors and other signaling agents. The RNA is present in a number of mouse tissues and in the developing mouse fetus. The HLH462 gene has been mapped by interspecific backcross analysis to the distal region of mouse chromosome 4. In its helix-loop-helix region HLH462 is closely related to the Id protein and the Drosophila emc protein. Like Id, HLH462 lacks a basic region required for DNA binding, and it inhibits the DNA-binding activities of other helix-loop-helix proteins. On the basis of its structural and functional similarity to Id, we suggest that HLH462 may inhibit the activities of helix-loop-helix transcription factors during the cellular growth response and during development.

Original languageEnglish (US)
Pages (from-to)1815-1819
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume88
Issue number5
DOIs
StatePublished - 1991

Keywords

  • Cell proliferation
  • Inhibitor of DNA binding
  • Mouse chromosome 4
  • Transcription factors

ASJC Scopus subject areas

  • General
  • Genetics

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