TY - JOUR
T1 - An antimicrobial peptide gene found in the male reproductive system of rats
AU - Li, P.
AU - Hsiao Chang Chan, Chang Chan
AU - He, B.
AU - Siu Cheung So, Cheung So
AU - Yiu Wa Chung, Wa Chung
AU - Shang, Q.
AU - Zhang, YD
AU - Zhang, YL
PY - 2001/3/2
Y1 - 2001/3/2
N2 - Little is known about the innate defense mechanisms of the male reproductive tract. We cloned a 385-base pair complementary DNA and its genomic DNA named Bin1b that is exclusively expressed in the caput region of the rat epididymis and that is responsible for sperm maturation, storage, and protection. Bin1b exhibits structural characteristics and antimicrobial activity similar to that of cationic antimicrobial peptides, β-defensins. Bin1b is maximally expressed when the rats are sexually mature and can be up-regulated by inflammation. Bin1b appears to be a natural epididymis-specific antimicrobial peptide that plays a role in reproductive tract host defense and male fertility.
AB - Little is known about the innate defense mechanisms of the male reproductive tract. We cloned a 385-base pair complementary DNA and its genomic DNA named Bin1b that is exclusively expressed in the caput region of the rat epididymis and that is responsible for sperm maturation, storage, and protection. Bin1b exhibits structural characteristics and antimicrobial activity similar to that of cationic antimicrobial peptides, β-defensins. Bin1b is maximally expressed when the rats are sexually mature and can be up-regulated by inflammation. Bin1b appears to be a natural epididymis-specific antimicrobial peptide that plays a role in reproductive tract host defense and male fertility.
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U2 - 10.1126/science.1056545
DO - 10.1126/science.1056545
M3 - Article
C2 - 11230693
AN - SCOPUS:0035793879
SN - 0036-8075
VL - 291
SP - 1783
EP - 1785
JO - Science
JF - Science
IS - 5509
ER -