An anatomic transcriptional atlas of human glioblastoma

Ralph B. Puchalski, Nameeta Shah, Jeremy Miller, Rachel Dalley, Steve R. Nomura, Jae Guen Yoon, Kimberly A. Smith, Michael Lankerovich, Darren Bertagnolli, Kris Bickley, Andrew F. Boe, Krissy Brouner, Stephanie Butler, Shiella Caldejon, Mike Chapin, Suvro Datta, Nick Dee, Tsega Desta, Tim Dolbeare, Nadezhda DotsonAmanda Ebbert, David Feng, Xu Feng, Michael Fisher, Garrett Gee, Jeff Goldy, Lindsey Gourley, Benjamin W. Gregor, Guangyu Gu, Nika Hejazinia, John Hohmann, Parvinder Hothi, Robert Howard, Kevin Joines, Ali Kriedberg, Leonard Kuan, Chris Lau, Felix Lee, Hwahyung Lee, Tracy Lemon, Fuhui Long, Naveed Mastan, Erika Mott, Chantal Murthy, Kiet Ngo, Eric Olson, Melissa Reding, Zack Riley, David Rosen, David Sandman, Nadiya Shapovalova, Clifford R. Slaughterbeck, Andrew Sodt, Graham Stockdale, Aaron Szafer, Wayne Wakeman, Paul E. Wohnoutka, Steven J. White, Don Marsh, Robert C. Rostomily, Lydia Ng, Chinh Dang, Allan Jones, Bart Keogh, Haley R. Gittleman, Jill S. Barnholtz-Sloan, Patrick J. Cimino, Megha S. Uppin, C. Dirk Keene, Farrokh R. Farrokhi, Justin D. Lathia, Michael E. Berens, Antonio Iavarone, Amy Bernard, Ed Lein, John W. Phillips, Steven W. Rostad, Charles Cobbs, Michael J. Hawrylycz, Greg D. Foltz

Research output: Contribution to journalArticlepeer-review

114 Scopus citations

Abstract

Glioblastoma is an aggressive brain tumor that carries a poor prognosis. The tumor’s molecular and cellular landscapes are complex, and their relationships to histologic features routinely used for diagnosis are unclear. We present the Ivy Glioblastoma Atlas, an anatomically based transcriptional atlas of human glioblastoma that aligns individual histologic features with genomic alterations and gene expression patterns, thus assigning molecular information to the most important morphologic hallmarks of the tumor. The atlas and its clinical and genomic database are freely accessible online data resources that will serve as a valuable platform for future investigations of glioblastoma pathogenesis, diagnosis, and treatment.

Original languageEnglish (US)
Pages (from-to)660-663
Number of pages4
JournalScience
Volume360
Issue number6389
DOIs
StatePublished - May 11 2018

ASJC Scopus subject areas

  • General

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