TY - JOUR
T1 - Amyotrophic Lateral Sclerosis
T2 - Associated Clinical Disorders and Immunological Evaluations
AU - Appel, Stanley H.
AU - Stockton Appel, Vicki
AU - Stewart, S. Scott
AU - Kerman, Ronald H.
PY - 1986/1/1
Y1 - 1986/1/1
N2 - We examined the family history and associated disease in 58 patients with amyotrophic lateral sclerosis (ALS), as well as the T-cell phenotypes and functions in 46 consecutive patients with this disorder. A family history of thyroid distribution was present in 19%, and an additional 21% of patients described family members with other possible autoimmune disorders. In 19% of the patients with ALS either past or present thyroid disease was documented. Eleven of 47 additional patients with ALS had significant elevations of microsomal and/or thyroglobulin antibody levels. The T-cell phenotypes and functions were comparable in the ALS and control groups, with the exception of the presence of Ia antigen. In patients with ALS, 11.9% of the T cells were positive for the Ia antigen, while in both a normal control population and a non-ALS neurologic disease population, only 6.4% of T cells have this antigenic determinant. These data support involvement of autoimmune mechanisms in ALS.
AB - We examined the family history and associated disease in 58 patients with amyotrophic lateral sclerosis (ALS), as well as the T-cell phenotypes and functions in 46 consecutive patients with this disorder. A family history of thyroid distribution was present in 19%, and an additional 21% of patients described family members with other possible autoimmune disorders. In 19% of the patients with ALS either past or present thyroid disease was documented. Eleven of 47 additional patients with ALS had significant elevations of microsomal and/or thyroglobulin antibody levels. The T-cell phenotypes and functions were comparable in the ALS and control groups, with the exception of the presence of Ia antigen. In patients with ALS, 11.9% of the T cells were positive for the Ia antigen, while in both a normal control population and a non-ALS neurologic disease population, only 6.4% of T cells have this antigenic determinant. These data support involvement of autoimmune mechanisms in ALS.
UR - http://www.scopus.com/inward/record.url?scp=0022626868&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022626868&partnerID=8YFLogxK
U2 - 10.1001/archneur.1986.00520030026007
DO - 10.1001/archneur.1986.00520030026007
M3 - Article
C2 - 3484947
AN - SCOPUS:0022626868
VL - 43
SP - 234
EP - 238
JO - Archives of neurology
JF - Archives of neurology
SN - 0003-9942
IS - 3
ER -