Amphiphilic triblock copolymer based on poly(p-dioxanone) and poly(ethylene glycol): Synthesis, characterization, and aqueous dispersion

K. C. Remant Bahadur, Santosh Aryal, Shanta Raj Bhattarai, Myung Seob Khil, Hak Yong Kim

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Amphiphilic triblock copolymers composed of poly(p-dioxanone) (PPDO) and poly(ethylene glycol) (PEG) were synthesized by ring opening polymerization of PDO initiated through dihydroxyl-terminated PEG in the presence of stannous 2-ethylhexanoate [Sn(oct)2] as a catalyst. Polymeric nanoparticles were prepared in an aqueous medium (triple distilled water and phosphate buffer pH 7.4) by cosolvent evaporation technique at room temperature (25°C). Stability of nanoparticles was significantly enough in triple distilled water when compared with the phosphate buffer. Core-shell geometry of polymeric nanoparticles was characterized by 1H-NMR spectroscopy and further confirmed by spectrophotometric analysis using pyrene as a probe. Variation in physicochemical characteristics of polymeric nanoparticles with the fraction of PPDO was investigated through the analysis of microscopic, spectroscopic, and light scattering techniques. Critical micelle concentration of polymer in triple distilled water decreased from 2.3 × 10-3 to 4.7 × 10-3. Atomic force microscopic observation revealed that polymeric nanoparticles were spherical and uniform with smooth textured of around 50-68 nm diameter. Dynamic light scattering and electrophoretic light scattering measurements showed a mono-disperse size distribution of around 113-171 nm hydrodynamic diameters and negative zeta (ζ)-potential (-4.00 to -5.87 mV), respectively. The investigation showed a significant effect of polymeric composition on the physicochemical characteristic of polymeric nanoparticies.

Original languageEnglish (US)
Pages (from-to)2695-2702
Number of pages8
JournalJournal of Applied Polymer Science
Volume103
Issue number4
DOIs
StatePublished - Feb 15 2007

Keywords

  • Biomaterial
  • Block copolymer
  • Coprecipitation
  • Nanoparticles
  • Polymerization

ASJC Scopus subject areas

  • Polymers and Plastics

Fingerprint Dive into the research topics of 'Amphiphilic triblock copolymer based on poly(p-dioxanone) and poly(ethylene glycol): Synthesis, characterization, and aqueous dispersion'. Together they form a unique fingerprint.

Cite this