Amitriptyline normalizes tetrabenazine-induced changes in cerebral microcirculation

Thomas A. Kent; Sheldon H. Preskorn; Robin K. Glotzbach; George H. Irwin

doi:10.1016/0006-3223(86)90190-3

Amitriptyline normalizes tetrabenazine-induced changes in cerebral microcirculation

Thomas A. Kent, Sheldon H. Preskorn, Robin K. Glotzbach, George H. Irwin

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Abstract

The cerebromicrocirculation in the tetrabenzaine (TBZ) model of depression has been found to be abnormal with respect to (1) responsiveness of cerebral blood flow to increases in arterial CO₂ content and (2) the effective permeability of the blood-brain barrier to water. Development of these abnormalities temporally paralleled the behavioral disturbances and catecholamine depletion induced by TBZ. These TBZ-induced changes occurred globally throughout the brain, being apparent in the forebrain, cerebellum, and medulla-pons. Pretreatment with the antidepressant amitriptyline prevented both behavioral and physiological effects of TBZ, whereas amitriptyline administered after TBZ was less effective. The results suggest that an important action of tricyclic antidepressants may be cerebromicrocirculatory effects.

Original language	English (US)
Pages (from-to)	483-491
Number of pages	9
Journal	Biological Psychiatry
Volume	21
Issue number	5-6
DOIs	https://doi.org/10.1016/0006-3223(86)90190-3
State	Published - May 1986

ASJC Scopus subject areas

Biological Psychiatry

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10.1016/0006-3223(86)90190-3

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title = "Amitriptyline normalizes tetrabenazine-induced changes in cerebral microcirculation",

abstract = "The cerebromicrocirculation in the tetrabenzaine (TBZ) model of depression has been found to be abnormal with respect to (1) responsiveness of cerebral blood flow to increases in arterial CO2 content and (2) the effective permeability of the blood-brain barrier to water. Development of these abnormalities temporally paralleled the behavioral disturbances and catecholamine depletion induced by TBZ. These TBZ-induced changes occurred globally throughout the brain, being apparent in the forebrain, cerebellum, and medulla-pons. Pretreatment with the antidepressant amitriptyline prevented both behavioral and physiological effects of TBZ, whereas amitriptyline administered after TBZ was less effective. The results suggest that an important action of tricyclic antidepressants may be cerebromicrocirculatory effects.",

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AU - Preskorn, Sheldon H.

AU - Glotzbach, Robin K.

AU - Irwin, George H.

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AB - The cerebromicrocirculation in the tetrabenzaine (TBZ) model of depression has been found to be abnormal with respect to (1) responsiveness of cerebral blood flow to increases in arterial CO2 content and (2) the effective permeability of the blood-brain barrier to water. Development of these abnormalities temporally paralleled the behavioral disturbances and catecholamine depletion induced by TBZ. These TBZ-induced changes occurred globally throughout the brain, being apparent in the forebrain, cerebellum, and medulla-pons. Pretreatment with the antidepressant amitriptyline prevented both behavioral and physiological effects of TBZ, whereas amitriptyline administered after TBZ was less effective. The results suggest that an important action of tricyclic antidepressants may be cerebromicrocirculatory effects.

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