Amiodarone and cyclophosphamide: Potential for enhanced lung toxicity

R. Bhagat, T. A. Sporn, G. D. Long, R. J. Folz

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Antineoplastic therapy can be associated with drug-induced lung toxicity. With the increasing use of amiodarone for cardiac dysrhythmias there is an increasing possibility of its combined use with chemotherapies for various malignancies. We report a patient on long-term amiodarone who developed biopsy-proven drug-induced lung toxicity after receiving high-dose cyclophosphamide, at a time-frame much shorter than would have been predicted with cyclophosphamide alone. The potential for enhanced lung toxicity secondary to combination of amiodarone and cyclophosphamide is discussed.

Original languageEnglish (US)
Pages (from-to)1109-1111
Number of pages3
JournalBone Marrow Transplantation
Issue number10
StatePublished - 2001


  • Amiodarone
  • Cyclophosphamide
  • Drug-induced lung toxicity
  • Interstitial pneumonitis
  • Oxidative stress

ASJC Scopus subject areas

  • Hematology
  • Transplantation


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