Amino alcohol modulation of hippocampal acetylcholine release

J. Robert Bostwick, Russell Abbe, Jilin Sun, Stanley H. Appel

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The synthesis and release of 3H-acetylcholine was measured in hippocampal slices of adult rat brain following acute in vitro exposure to ethanolamine. Evoked release of 3H-acetylcholine was elevated by 60-70% but 3H-acetylcholine synthesis was unaffected. Other amino alcohols were also found to significantly increase evoked 3H-acetylcholine release. The effect may be stereochemically mediated since only one of four possible propanolamine configurations, R-alaninol, was active. The most potent compound tested was R-prolinol which showed an EC50 nearly 10-fold lower than that of either R-alaninol or ethanolamine; S-prolinol was inactive. Slices taken from adult rats which had been fed active compounds for two weeks also exhibited enhancements in evoked 3H-acetylcholine release. These results indicate that amino alcohols modulate acetylcholine release in the rat hippocampus.

Original languageEnglish (US)
Pages (from-to)425-428
Number of pages4
JournalNeuroReport
Volume3
Issue number5
DOIs
StatePublished - May 1992

Keywords

  • Acetylcholine release
  • Amino alcohol
  • Ethanolamine
  • Hippocampus
  • Modulation

ASJC Scopus subject areas

  • Neuroscience(all)

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