Amenorrhea-galactorrhea and craniopharyngioma

Ridha Arem, William A. Zoghbi, Lawrence Chan

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


A 40-year-old woman had a 1-year history of amenorrhea-galactorrhea. She was found to have an intrasellar tumor with suprasellar extension and a prolactin level of 98.1 ng/mL. Subtotal resection of the tumor resulted in a return of the prolactin level to normal within 4 days of the operation and of the prolactin response to thyrotropin releasing hormone, accompanied by the disappearance of the galactorrhea. Histologic examination revealed a typical craniopharyngioma. These observations indicate that one important mechanism of hyperprolactinemia in patients with craniopharyngioma is direct encroachment on the hypothalamus and/or pituitary stalk by the tumor and interruption of prolactin inhibiting factor.

Original languageEnglish (US)
Pages (from-to)109-112
Number of pages4
JournalSurgical Neurology
Issue number2
StatePublished - Aug 1983


  • Amenorrhea
  • Craniopharyngioma
  • Galactorrhea
  • Hyperprolactinemia
  • Prolactin

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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