Alpha-mannosidosis: Report of a case with morphologic, cytologic and immunohistochemical considerations

B. Krishnan, Dina R. Mody, I. Ramzy

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

We report the histopathologic features of the knee bone and synovium and the cytologic features of the synovial fluid from a patient with alpha- mannosidosis. The synovium showed marked papillary hyperplasia with infiltration of foamy histiocytes containing periodic acid-Schiff-positive, diastase-resistant material. Severe degenerative changes were seen in the knee bone. The synovial fluid showed increased numbers of macrophages containing periodic acid-Schiff-positive, diastase-resistant material. The differential diagnostic considerations in the synovial fluid are also discussed.

Original languageEnglish (US)
Pages (from-to)441-445
Number of pages5
JournalActa Cytologica
Volume38
Issue number3
StatePublished - Jan 1 1994

Keywords

  • immunohistochemistry
  • knee
  • mannosidosis

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology
  • Histology

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