Allografts positive for hepatitis B surface antigen in liver transplant for disease related to hepatitis B virus

Weiqiang Ju, Maogen Chen, Zhiyong Guo, Dongping Wang, Xiaofeng Zhu, Jiefu Huang, Xiaoshun He

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Objectives: Liver grafts from hepatitis B surface antigen-negative and anti-core antibody-positive donors are safe for liver transplant. However, the use of hepatitis B surface antigen-positive liver donors in liver transplants is controversial. We assessed the safety and effectiveness of liver transplants using hepatitis B surface antigenpositive liver grafts to patients with diseases related to hepatitis B virus. Materials and Methods: We retrospectively reviewed 23 patients who had a deceased-donor liver transplant using hepatitis B surface antigenpositive liver grafts. All patients had end-stage liver disease secondary to hepatitis B virus infection. Recipients had oral entecavir and intravenous or intramuscular injection of hepatitis B immune globulin for > 1 year after the transplant. Results: Two patients died from severe perioperative pneumonia, and the other 21 patients were followed for 9 to 38 months after transplant. All 21 patients remained hepatitis B surface antigenpositive. A repeat liver transplant was performed in 1 patient at 5 months after the initial transplant because of biliary ischemia. There were 3 patients who died from recurrent liver cancer at 9, 14, and 18 months after transplant. There were 18 patients (78%) who survived and 17 grafts (74%) that survived. Conclusions: Liver transplant using hepatitis B surface antigen-positive liver grafts is safe for patients with end-stage liver disease secondary to hepatitis B virus infection.

Original languageEnglish (US)
Pages (from-to)245-249
Number of pages5
JournalExperimental and Clinical Transplantation
Volume11
Issue number3
DOIs
StatePublished - Jun 2013

Keywords

  • Antibody
  • Cancer
  • Hepatic failure
  • Immune globulin

ASJC Scopus subject areas

  • Transplantation

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