Abstract
Due to the inability to cure multiple myeloma (MM) with current therapies, including autologous stem cell transplantation (auto-SCT), there has been a sustained interest in allogeneic hematopoietic cell transplantation (allo-HCT) given its use of a myeloma-free donor cell graft and the possibility of a donor-driven, immune-mediated graft-versus-MM effect. This chapter begins with a discussion on the risks of allo-HCT in MM. Several randomized trials have attempted to evaluate the tandem auto-SCT-allo-HCT approach versus tandem auto-SCT in the upfront transplant setting. The chapter explains when allo-HCT can be offered in the disease course of MM. It also presents two case studies dealing with the genetically defined high-risk myeloma in a young patient and plasma cell leukemia (PCL). It concludes with a discussion on lenalidomide (LEN), and bortezomib.
Original language | English (US) |
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Title of host publication | Cancer Consult |
Subtitle of host publication | Expertise for Clinical Practice |
Publisher | Wiley |
Pages | 381-387 |
Number of pages | 7 |
ISBN (Electronic) | 9781118589199 |
ISBN (Print) | 9781118589212 |
DOIs | |
State | Published - Jun 20 2014 |
Keywords
- Allogeneic hematopoietic cell transplantation (allo-HCT)
- Autologous stem cell transplantation (auto-SCT)
- Lenalidomide (LEN)
- Multiple myeloma (MM)
- Plasma cell leukemia (PCL)
ASJC Scopus subject areas
- Medicine(all)