Alendronate functionalized mesoporous bioactive glass nanospheres

Elisa Boanini, Silvia Panseri, Fabiola Arroyo, Monica Montesi, Katia Rubini, Anna Tampieri, Cristian Covarrubias, Adriana Bigi

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

In this work we synthesized mesoporous bioactive glass nanospheres (nMBG) with the aim to utilize them as substrates for loading one of the most potent amino-bisphosphonates, alendronate (AL). The results of the chemical and structural characterization show that the nMBG display a relatively high surface area (528 m2/g) and a mean pore volume of 0.63 cm3/g, both of which decrease on increasing alendronate content. It is possible to modulate the amount of AL loaded into the nanospheres up to a maximum value of about 17 wt %. In vitro tests were performed using a human osteosarcoma cell line (MG63) and a murine monocyte/macrophage cell line as osteoclast model (RAW 264.7). The results indicate that even the lower concentration of alendronate provokes decreased tumor cell viability, and that osteoclast activity exhibits an alendronate dose-dependent inhibition. The data suggest that nMBG can act as a suitable support for the local delivery of alendronate, and that the antiresorptive and antitumor properties of the functionalized mesoporous nanospheres can be modulated by varying the amount of alendronate loading.

Original languageEnglish (US)
Article number135
JournalMaterials
Volume9
Issue number3
DOIs
StatePublished - Feb 26 2016

Keywords

  • Alendronate
  • Anti-cancer
  • Bioactive glass nanospheres
  • Mesoporous
  • Osteoclast inhibition

ASJC Scopus subject areas

  • Materials Science(all)

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