TY - JOUR
T1 - Alcohol-related liver and extrahepatic malignancies
T2 - burden of disease and socioeconomic disparities in 2019
AU - Danpanichkul, Pojsakorn
AU - Suparan, Kanokphong
AU - Chaiyakunapruk, Nathorn
AU - Auttapracha, Thanida
AU - Kongarin, Siwanart
AU - Wattanachayakul, Phuuwadith
AU - Ramadoss, Vijay
AU - Suenghataiphorn, Thanathip
AU - Sukphutanan, Banthoon
AU - Pang, Yanfang
AU - Lui, Rashid N.
AU - Yang, Ju Dong
AU - Noureddin, Mazen
AU - Díaz, Luis Antonio
AU - Liangpunsakul, Suthat
AU - Arab, Juan Pablo
AU - Wijarnpreecha, Karn
N1 - Publisher Copyright:
Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2025/2/1
Y1 - 2025/2/1
N2 - BACKGROUND: Alcohol is linked to various cancers. While many studies have focused on developed countries, the burden of alcohol-related cancers in developing countries remains underexplored. METHODS: We analyzed data from the Global Burden of Disease Study (2000-2019) to assess mortality and disability-adjusted life years (DALYs) from alcohol-related cancers in low and low-to-middle sociodemographic index (SDI) countries. RESULTS: In 2019, there were 494 730 mortality from alcohol-related cancer. Low and low-middle SDI countries contributed over 15% of global mortality of alcohol-related cancer. Among multiple types of cancer, other pharyngeal cancers in these countries accounted for over 30% of global mortality of alcohol-related cancer. Primary liver cancer exhibited the highest mortality ( n = 16 090) in low and low-middle SDI countries. While deaths and DALYs rates from alcohol-related cancers decreased globally between 2000 and 2019, the related burden increased in low and low-middle SDI countries with a rise in all types of alcohol-related cancers, except for primary liver cancer. The most rapidly growing mortality rates in low SDI were from other pharyngeal cancers (+2.25%), whereas in low-middle SDI countries, colorectal cancer evidenced the highest increase (+2.76%). CONCLUSION: The burden from alcohol-related cancer has risen in countries with low and low-to-middle SDI, especially other pharyngeal cancers and colorectal cancer. Policymakers should focus on improving alcohol-related policies as well as screening availability to tackle the associated burden of cancer in resource-constrained countries. However, the difficulty in isolating the impact of alcohol due to limited data on other confounders necessitates caution in interpreting these findings.
AB - BACKGROUND: Alcohol is linked to various cancers. While many studies have focused on developed countries, the burden of alcohol-related cancers in developing countries remains underexplored. METHODS: We analyzed data from the Global Burden of Disease Study (2000-2019) to assess mortality and disability-adjusted life years (DALYs) from alcohol-related cancers in low and low-to-middle sociodemographic index (SDI) countries. RESULTS: In 2019, there were 494 730 mortality from alcohol-related cancer. Low and low-middle SDI countries contributed over 15% of global mortality of alcohol-related cancer. Among multiple types of cancer, other pharyngeal cancers in these countries accounted for over 30% of global mortality of alcohol-related cancer. Primary liver cancer exhibited the highest mortality ( n = 16 090) in low and low-middle SDI countries. While deaths and DALYs rates from alcohol-related cancers decreased globally between 2000 and 2019, the related burden increased in low and low-middle SDI countries with a rise in all types of alcohol-related cancers, except for primary liver cancer. The most rapidly growing mortality rates in low SDI were from other pharyngeal cancers (+2.25%), whereas in low-middle SDI countries, colorectal cancer evidenced the highest increase (+2.76%). CONCLUSION: The burden from alcohol-related cancer has risen in countries with low and low-to-middle SDI, especially other pharyngeal cancers and colorectal cancer. Policymakers should focus on improving alcohol-related policies as well as screening availability to tackle the associated burden of cancer in resource-constrained countries. However, the difficulty in isolating the impact of alcohol due to limited data on other confounders necessitates caution in interpreting these findings.
KW - Humans
KW - Global Burden of Disease
KW - Liver Neoplasms/epidemiology
KW - Male
KW - Female
KW - Socioeconomic Factors
KW - Disability-Adjusted Life Years
KW - Developing Countries
KW - Middle Aged
KW - Alcohol Drinking/adverse effects
KW - Health Status Disparities
KW - Cost of Illness
KW - Neoplasms/epidemiology
KW - Aged
KW - Risk Factors
KW - Socioeconomic Disparities in Health
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U2 - 10.1097/MEG.0000000000002882
DO - 10.1097/MEG.0000000000002882
M3 - Article
C2 - 39589794
AN - SCOPUS:85213596308
SN - 0954-691X
VL - 37
SP - 198
EP - 206
JO - European Journal of Gastroenterology and Hepatology
JF - European Journal of Gastroenterology and Hepatology
IS - 2
ER -