Background: Estrogen supplementation enhances voluntary alcohol consumption in ovariectomized rodents. The effects of the enhanced alcohol consumption on post-infarct myocardial repair are unknown. Results: Ethanol-mediated suppression of endothelial progenitor cells produces diminished post-ischemic left ventricular function. Conclusion: Estrogen-induced increases in alcohol consumption negatively compete with the cardioprotective effects of estrogen. Significance: Alcohol consumption during estrogen replacement therapy must be observed closely.
|Original language||English (US)|
|Number of pages||13|
|Journal||Journal of Biological Chemistry|
|State||Published - Jun 21 2013|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology