Albuminuria and Heart Failure: JACC State-of-the-Art Review

Muhammad Shahzeb Khan, Izza Shahid, Stefan D. Anker, Gregg C. Fonarow, Marat Fudim, Michael E. Hall, Adrian Hernandez, Alanna A. Morris, Tariq Shafi, Matthew R. Weir, Faiez Zannad, George L. Bakris, Javed Butler

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


Although chronic kidney disease is characterized by low glomerular filtration rate (GFR) or albuminuria, estimated GFR (eGFR) is more widely utilized as a marker of risk profile in cardiovascular diseases, including heart failure (HF). The presence and magnitude of albuminuria confers a strong prognostic association in forecasting risk of incident HF as well as its progression, irrespective of eGFR. Despite the high prevalence of albuminuria in HF, whether it adds incremental prognostic information in clinical practice and serves as an independent risk marker, and whether there are any therapeutic implications of assessing albuminuria in patients with HF is less well-established. In this narrative review, we assess the potential role of albuminuria in risk profiling for development and progression of HF, strengths and limitations of utilizing albuminuria as a risk marker, its ability to serve in HF risk prediction models, and the implications of adopting albuminuria as an effective parameter in cardiovascular trials and practice.

Original languageEnglish (US)
Pages (from-to)270-282
Number of pages13
JournalJournal of the American College of Cardiology
Issue number3
StatePublished - Jan 24 2023


  • albuminuria
  • clinical trials
  • heart failure
  • Heart Failure/epidemiology
  • Cardiovascular Diseases
  • Glomerular Filtration Rate
  • Albuminuria/epidemiology
  • Humans
  • Risk Factors
  • Renal Insufficiency, Chronic/epidemiology

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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