AKXD recombinant inbred strains: Models for studying the molecular genetic basis of murine lymphomas

M. L. Mucenski, B. A. Taylor, N. A. Jenkins, N. G. Copeland

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

We analyzed the lymphoma susceptibility of 13 AKXD recombinant inbred mouse strains derived from AKR/J, a highly lymphomatous strain, and DBA/2J, a weakly lymphomatous strain. Of the 13 strains used, 12 showed a high incidence of lymphoma development. However, the average age at onset of lymphoma varied considerably among the different AKXD strains, suggesting that they have segregated several loci that affect lymphoma susceptibility. A relatively unambiguous classification of lymphomas was made possible by using histopathology in addition to detailed molecular characterization of rearrangements in immunoglobulin heavy and kappa light genes and in T-cell receptor β-chain genes. Among the 12 highly lymphomatous strains, only 2 were identified that, like the parental AKR/J strain, died primarily of T-cell lymphomas. Three strains died primarily of B-cell lymphomas, and one strain primarily of myeloid lymphomas. Six strains were susceptible to both T-cell and B-cell lymphomas. Thus, these strains have segregated genes that affect both lymphoma susceptibility and lymphoma type and should prove to be useful models for studying the molecular genetic basis of murine lymphomas.

Original languageEnglish (US)
Pages (from-to)4236-4243
Number of pages8
JournalMolecular and Cellular Biology
Volume6
Issue number12
DOIs
StatePublished - 1986

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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