TY - JOUR
T1 - Air force/Texas Coronary Atherosclerosis Prevention study (AFCAPS/TexCAPS)
T2 - Baseline Characteristics and comparison with USA population
AU - Clearfield, Michael
AU - Whitney, Edwin J.
AU - Weis, Stephen
AU - Downs, John R.
AU - Shapiro, Deborah R.
AU - Stein, Evan A.
AU - Watson, Douglas J.
AU - Langendörfer, Alexandra
AU - Beere, Polly A.
AU - Stamler, Jeremiah
AU - Gotto, Antonio M.
PY - 2000
Y1 - 2000
N2 - Background: Results of the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS) demonstrated that treatment with lovastatin, in addition to modifications of diet and lifestyle, reduced the rate of first acute major coronary events compared with placebo in a cohort that included participants with average to mildly elevated total levels of cholesterol, and below average levels of high-density lipoprotein cholesterol, women, and elderly subjects. Objective: To describe the baseline characteristics of the study's cohort. Design: This was a double-blind, placebo-controlled, primary-prevention trial in which Americans with average to mildly elevated total levels of cholesterol [4.65-6.83 mmol/l (180-264 mg/dl)] and no clinical evidence of atherosclerotic cardiovascular disease were randomly allocated either 20-40 mg/day lovastatin or placebo in addition to a low-saturated fat, low-cholesterol diet. Baseline characteristics of the study cohort are described, and the characteristics of a USA reference population based upon NHANES III data are provided for comparison. Results: The study includes 5608 men (85%) and 997 women (15%) with mean total cholesterol level 5.71 ± 0.54 mmol/I (221 ± 21 mg/dl), low-density lipoprotein cholesterol level 3.88 ± 0.44 mmol/I (150 ± 17 mg/dl), high- density lipoprotein cholesterol 0.96 ± 0.15 mmol/I (37 ± 6 mg/dl), and median triglyceride level 1.78 ± 0.86 mmol/I (158 ± 76 mg/dl). The mean age is 58 years (ranges 45-73 years for men and 55-73 years for women). The participants are 89% white, 7% Hispanic, and 3% black. Conclusion: Results from AFCAPS/TexCAPS will be applicable to large segments of populations; in the USA alone, eight million share the demographic and baseline-lipid-level characteristics of the study cohort. (C) 2000 Lippincott Williams and Wilkins.
AB - Background: Results of the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS) demonstrated that treatment with lovastatin, in addition to modifications of diet and lifestyle, reduced the rate of first acute major coronary events compared with placebo in a cohort that included participants with average to mildly elevated total levels of cholesterol, and below average levels of high-density lipoprotein cholesterol, women, and elderly subjects. Objective: To describe the baseline characteristics of the study's cohort. Design: This was a double-blind, placebo-controlled, primary-prevention trial in which Americans with average to mildly elevated total levels of cholesterol [4.65-6.83 mmol/l (180-264 mg/dl)] and no clinical evidence of atherosclerotic cardiovascular disease were randomly allocated either 20-40 mg/day lovastatin or placebo in addition to a low-saturated fat, low-cholesterol diet. Baseline characteristics of the study cohort are described, and the characteristics of a USA reference population based upon NHANES III data are provided for comparison. Results: The study includes 5608 men (85%) and 997 women (15%) with mean total cholesterol level 5.71 ± 0.54 mmol/I (221 ± 21 mg/dl), low-density lipoprotein cholesterol level 3.88 ± 0.44 mmol/I (150 ± 17 mg/dl), high- density lipoprotein cholesterol 0.96 ± 0.15 mmol/I (37 ± 6 mg/dl), and median triglyceride level 1.78 ± 0.86 mmol/I (158 ± 76 mg/dl). The mean age is 58 years (ranges 45-73 years for men and 55-73 years for women). The participants are 89% white, 7% Hispanic, and 3% black. Conclusion: Results from AFCAPS/TexCAPS will be applicable to large segments of populations; in the USA alone, eight million share the demographic and baseline-lipid-level characteristics of the study cohort. (C) 2000 Lippincott Williams and Wilkins.
KW - Cholesterol
KW - Controlled clinical trials
KW - Lovastatin
KW - Primary prevention
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U2 - 10.1177/204748730000700207
DO - 10.1177/204748730000700207
M3 - Article
C2 - 10879416
AN - SCOPUS:84910077025
SN - 1350-6277
VL - 7
SP - 125
EP - 133
JO - Journal of Cardiovascular Risk
JF - Journal of Cardiovascular Risk
IS - 2
ER -