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Aging Overview and In-Depth Analysis

Vrushali Bhalchim, Vrushali Neve, Namrata Sarma, Mohini Rana, Muthuraju Sangu

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The scientific community has an advanced understanding of aging mechanisms, which involve physiological decline and increased disease susceptibility. Animal models have proven valuable in studying aging mechanisms in controlled settings. The reversible nature of epigenetic information offers potential for aging-related therapies. The accumulation of molecular and cellular metabolic side effects drives aging-related decline. This model reflects death age distribution in populations protected from age-independent causes, leading to the exploration of metabolic damage repair interventions. Evidence shows that targeting tissue-specific metabolic pathways could be a promising antiaging strategy. Understanding these pathway interactions may improve therapies for metabolic dysfunction and age-related diseases. Aging research requires a multidimensional approach. Epigenetics has revealed DNA methylation, histone modifications, and chromatin remodeling as aging hallmarks. The reversibility of these changes has sparked interest in drugs targeting age-associated epigenetic alterations. Researchers emphasize ethical and environmental considerations in human aging studies. Scientific progress in understanding aging mechanisms offers hope for improving later-life quality.

Original languageEnglish (US)
Title of host publicationThe Gut-Brain Axis in Neurological Disorders
Subtitle of host publicationClinical Implications and Holistic Management
PublisherCRC Press
Pages79-94
Number of pages16
ISBN (Electronic)9781040560136
ISBN (Print)9781041005223
DOIs
StatePublished - Jan 1 2026

ASJC Scopus subject areas

  • General Neuroscience
  • General Medicine
  • General Biochemistry, Genetics and Molecular Biology
  • General Agricultural and Biological Sciences

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