Abstract
The scientific community has an advanced understanding of aging mechanisms, which involve physiological decline and increased disease susceptibility. Animal models have proven valuable in studying aging mechanisms in controlled settings. The reversible nature of epigenetic information offers potential for aging-related therapies. The accumulation of molecular and cellular metabolic side effects drives aging-related decline. This model reflects death age distribution in populations protected from age-independent causes, leading to the exploration of metabolic damage repair interventions. Evidence shows that targeting tissue-specific metabolic pathways could be a promising antiaging strategy. Understanding these pathway interactions may improve therapies for metabolic dysfunction and age-related diseases. Aging research requires a multidimensional approach. Epigenetics has revealed DNA methylation, histone modifications, and chromatin remodeling as aging hallmarks. The reversibility of these changes has sparked interest in drugs targeting age-associated epigenetic alterations. Researchers emphasize ethical and environmental considerations in human aging studies. Scientific progress in understanding aging mechanisms offers hope for improving later-life quality.
| Original language | English (US) |
|---|---|
| Title of host publication | The Gut-Brain Axis in Neurological Disorders |
| Subtitle of host publication | Clinical Implications and Holistic Management |
| Publisher | CRC Press |
| Pages | 79-94 |
| Number of pages | 16 |
| ISBN (Electronic) | 9781040560136 |
| ISBN (Print) | 9781041005223 |
| DOIs | |
| State | Published - Jan 1 2026 |
ASJC Scopus subject areas
- General Neuroscience
- General Medicine
- General Biochemistry, Genetics and Molecular Biology
- General Agricultural and Biological Sciences
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