Aggressive peripheral CD70-positive t-cell lymphoma associated with severe chronic active EBV infection

Donald R. Shaffer; Andrea M. Sheehan; Zhongzhen Yi; Cheryl C. Rodgers; Catherine M. Bollard; Malcolm Brenner; Cliona M. Rooney; Helen Heslop; Stephen Gottschalk

doi:10.1002/pbc.23352

Aggressive peripheral CD70-positive t-cell lymphoma associated with severe chronic active EBV infection

Donald R. Shaffer, Andrea M. Sheehan, Zhongzhen Yi, Cheryl C. Rodgers, Catherine M. Bollard, Malcolm Brenner, Cliona M. Rooney, Helen Heslop, Stephen Gottschalk

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Severe chronic active Epstein-Barr virus infection (CAEBV) in T or NK cells is a rare complication of latent EBV infection. CAEBV associated T-cell lymphoproliferative disease (LPD) consists of polyclonal lesions as well as aggressive lymphomas. Here, we report such a patient. In addition, we show that this primary CAEBV associated T-cell lymphoma expresses CD70 and is sensitive to killing by CD70-specific T cells, identifying CD70 as a potential immunotherapeutic target for CAEBV-associated T-cell lymphoma. Pediatr Blood Cancer 2012;59:758-761.

Original language	English (US)
Pages (from-to)	758-761
Number of pages	4
Journal	Pediatric Blood and Cancer
Volume	59
Issue number	4
DOIs	https://doi.org/10.1002/pbc.23352
State	Published - Oct 2012

Keywords

CD70
EBV
Immunotherapy
Lymphoma

ASJC Scopus subject areas

Oncology
Pediatrics, Perinatology, and Child Health
Hematology

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10.1002/pbc.23352

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title = "Aggressive peripheral CD70-positive t-cell lymphoma associated with severe chronic active EBV infection",

abstract = "Severe chronic active Epstein-Barr virus infection (CAEBV) in T or NK cells is a rare complication of latent EBV infection. CAEBV associated T-cell lymphoproliferative disease (LPD) consists of polyclonal lesions as well as aggressive lymphomas. Here, we report such a patient. In addition, we show that this primary CAEBV associated T-cell lymphoma expresses CD70 and is sensitive to killing by CD70-specific T cells, identifying CD70 as a potential immunotherapeutic target for CAEBV-associated T-cell lymphoma. Pediatr Blood Cancer 2012;59:758-761.",

keywords = "CD70, EBV, Immunotherapy, Lymphoma",

author = "Shaffer, \{Donald R.\} and Sheehan, \{Andrea M.\} and Zhongzhen Yi and Rodgers, \{Cheryl C.\} and Bollard, \{Catherine M.\} and Malcolm Brenner and Rooney, \{Cliona M.\} and Helen Heslop and Stephen Gottschalk",

year = "2012",

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doi = "10.1002/pbc.23352",

language = "English (US)",

volume = "59",

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T1 - Aggressive peripheral CD70-positive t-cell lymphoma associated with severe chronic active EBV infection

AU - Shaffer, Donald R.

AU - Sheehan, Andrea M.

AU - Yi, Zhongzhen

AU - Rodgers, Cheryl C.

AU - Bollard, Catherine M.

AU - Brenner, Malcolm

AU - Rooney, Cliona M.

AU - Heslop, Helen

AU - Gottschalk, Stephen

PY - 2012/10

Y1 - 2012/10

N2 - Severe chronic active Epstein-Barr virus infection (CAEBV) in T or NK cells is a rare complication of latent EBV infection. CAEBV associated T-cell lymphoproliferative disease (LPD) consists of polyclonal lesions as well as aggressive lymphomas. Here, we report such a patient. In addition, we show that this primary CAEBV associated T-cell lymphoma expresses CD70 and is sensitive to killing by CD70-specific T cells, identifying CD70 as a potential immunotherapeutic target for CAEBV-associated T-cell lymphoma. Pediatr Blood Cancer 2012;59:758-761.

AB - Severe chronic active Epstein-Barr virus infection (CAEBV) in T or NK cells is a rare complication of latent EBV infection. CAEBV associated T-cell lymphoproliferative disease (LPD) consists of polyclonal lesions as well as aggressive lymphomas. Here, we report such a patient. In addition, we show that this primary CAEBV associated T-cell lymphoma expresses CD70 and is sensitive to killing by CD70-specific T cells, identifying CD70 as a potential immunotherapeutic target for CAEBV-associated T-cell lymphoma. Pediatr Blood Cancer 2012;59:758-761.

KW - CD70

KW - EBV

KW - Immunotherapy

KW - Lymphoma

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DO - 10.1002/pbc.23352

M3 - Article

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AN - SCOPUS:84864944376

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VL - 59

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JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

IS - 4

ER -

Aggressive peripheral CD70-positive t-cell lymphoma associated with severe chronic active EBV infection

Abstract

Keywords

ASJC Scopus subject areas

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