Aggressive peripheral CD70-positive t-cell lymphoma associated with severe chronic active EBV infection

Donald R. Shaffer, Andrea M. Sheehan, Zhongzhen Yi, Cheryl C. Rodgers, Catherine M. Bollard, Malcolm Brenner, Cliona M. Rooney, Helen Heslop, Stephen Gottschalk

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Severe chronic active Epstein-Barr virus infection (CAEBV) in T or NK cells is a rare complication of latent EBV infection. CAEBV associated T-cell lymphoproliferative disease (LPD) consists of polyclonal lesions as well as aggressive lymphomas. Here, we report such a patient. In addition, we show that this primary CAEBV associated T-cell lymphoma expresses CD70 and is sensitive to killing by CD70-specific T cells, identifying CD70 as a potential immunotherapeutic target for CAEBV-associated T-cell lymphoma. Pediatr Blood Cancer 2012;59:758-761.

Original languageEnglish (US)
Pages (from-to)758-761
Number of pages4
JournalPediatric Blood and Cancer
Volume59
Issue number4
DOIs
StatePublished - Oct 2012

Keywords

  • CD70
  • EBV
  • Immunotherapy
  • Lymphoma

ASJC Scopus subject areas

  • Oncology
  • Pediatrics, Perinatology, and Child Health
  • Hematology

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