Abstract
Severe chronic active Epstein-Barr virus infection (CAEBV) in T or NK cells is a rare complication of latent EBV infection. CAEBV associated T-cell lymphoproliferative disease (LPD) consists of polyclonal lesions as well as aggressive lymphomas. Here, we report such a patient. In addition, we show that this primary CAEBV associated T-cell lymphoma expresses CD70 and is sensitive to killing by CD70-specific T cells, identifying CD70 as a potential immunotherapeutic target for CAEBV-associated T-cell lymphoma. Pediatr Blood Cancer 2012;59:758-761.
Original language | English (US) |
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Pages (from-to) | 758-761 |
Number of pages | 4 |
Journal | Pediatric Blood and Cancer |
Volume | 59 |
Issue number | 4 |
DOIs | |
State | Published - Oct 2012 |
Keywords
- CD70
- EBV
- Immunotherapy
- Lymphoma
ASJC Scopus subject areas
- Oncology
- Pediatrics, Perinatology, and Child Health
- Hematology