Aggressive Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Review

Neha Desai, Mukul K. Divatia, Aniket Jadhav, Aditya Wagh

Research output: Contribution to journalReview articlepeer-review


Non-melanoma skin cancer of the head and neck (NMSCHN) is one of the most common malignancies worldwide, and its incidence is growing at a significant rate. It has been found to be aggressive in its spread and has the capacity to metastasize to regional lymph nodes. Cutaneous squamous cell carcinoma (cSCC) has a considerably high mortality rate. It has remarkable characteristics: diameter >2 cm, depth >5 mm, high recurrence, perineural invasion, and locoregional metastases. Aggressive cSCC lesions most commonly metastasize to the parotid gland. Also, immunocompromised patients have a higher risk of developing this aggressive cancer along with the worst prognostic outcomes. It is very important to discuss and assess the risk factors, prognostic factors, and outcomes of patients with cSCC, which will give clinicians future directives for making modifications to their treatment plans. The successful treatment of aggressive cSCC of the head and neck includes early detection and diagnosis, surgery alone or adjuvant chemotherapy, and radiotherapy as required. Multimodal therapy options should be considered by clinicians for better outcomes of aggressive cSCC of the head and neck.

Original languageEnglish (US)
Pages (from-to)6634-6647
Number of pages14
JournalCurrent Oncology
Issue number7
StatePublished - Jul 11 2023


  • aggressive cutaneous squamous cell carcinoma
  • head and neck region
  • metastatic
  • non-melanoma cancer
  • review
  • Head and Neck Neoplasms/diagnosis
  • Humans
  • Carcinoma, Squamous Cell/diagnosis
  • Squamous Cell Carcinoma of Head and Neck/therapy
  • Neoplasm Staging
  • Skin Neoplasms/diagnosis

ASJC Scopus subject areas

  • Oncology


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