Age-related elemental change in bones

C. Wang, M. H. Eisa, W. Jin, H. Shen, Y. Mi, J. Gao, Y. Zhou, H. Yao, Y. Zhao

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


To investigate age dependence of the bone element contents and structure, lumbar and femur from Sprague-Dawley (SD) rats were chosen for their more susceptibility to fracture. These rats were divided into to 5 age groups: 1, 4, 7, 11 and 25 month-age, corresponding human beings from the young to the old. The elements contents were detected by external Proton Induced X-ray emission (PIXE) technique. X-ray Absorption Fine Structure (XAFS) method was also applied to obtain information about calcium (Ca) and phosphor (P) structure. It was found that Ca content, Ca/P ratio, valance state of Ca and P and their coordinate structure remains unaltered with age variance, whereas the content of strontium (Sr) was significantly decreasing. Sr concentration may provide a new parameter for diagnosis of bone disorder.

Original languageEnglish (US)
Pages (from-to)1619-1622
Number of pages4
JournalNuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms
Issue number8
StatePublished - Apr 2008


  • Age
  • Calcium
  • Osteoporosis
  • PIXE
  • Strontium
  • XAFS

ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Instrumentation


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