Age-dependent modulation of tissue-specific repair activity for 3-methyladenine and O6-methylguanine in DNA in inbred mice

Willie J. Washington, Robert S. Foote, William C. Dunn, Walderico M. Generoso, Sankar Mitra

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

3-Methyladenine-DNA N-glycosylase (MAG) and O6-methylguanine-DNA methyltransferase (MGMT) activities were assayed in liver, lungs, brain and ovaries of female mice of two inbred stocks, C3Hf and C57BL/E, as a function of age. In addition to differences in the enzyme levels between the two stocks for each organ, the suckling animals (9-day-old) have consistently lower levels of both MAG and MGMT than young adults (7-or 8-week-old). While the MGMT levels in adults did not decrease with age, the MAG levels in 15- to 17-month-old animals were, in general, significantly lower than those in young aduts. These results raise the possibility that the older animals are at higher risk than young adults following exposure to alkylating mutagens.

Original languageEnglish (US)
Pages (from-to)43-52
Number of pages10
JournalMechanisms of Ageing and Development
Volume48
Issue number1
DOIs
StatePublished - Jan 1 1989

Keywords

  • 3-Methyladenine-DNA N-glycoyslase
  • Ageing
  • DNA repir
  • O-Methylguanine-DNA methyltransferase
  • Tissue specificity

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology
  • Biochemistry
  • Aging

Fingerprint Dive into the research topics of 'Age-dependent modulation of tissue-specific repair activity for 3-methyladenine and O<sup>6</sup>-methylguanine in DNA in inbred mice'. Together they form a unique fingerprint.

Cite this