Age-adjusted comorbidity and survival in locally advanced laryngeal cancer

Multidisciplinary Larynx Cancer Working Group

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Background: The purpose of this study was to quantify the relationship among age, pretreatment comorbidity, and survival outcomes in patients with locally advanced laryngeal cancer. Methods: Baseline comorbidity data were collected and age-adjusted Charlson Comorbidity Index (CCI) was calculated for each case. Kaplan-Meier and Cox proportional hazards modeling were used to determine associations with survival. Results: For 548 patients, with a median age of 59 years (range 31-91 years), 58% were treated with larynx preservation and the rest with total laryngectomy and adjuvant radiotherapy (RT). Two hundred thirty-eight patients (43%) had at least 1 comorbidity each. Cardiovascular diseases were the most common comorbidities (19%). The 5-year overall survival (OS) for patients with CCI ≤3 (n = 442) were superior to CCI >3 (n = 106; 60% vs 41%; P <.0001), although the 5-year disease-specific survival (DSS) rates were not significantly different. The 5-year noncancer CSS was better for age-adjusted CCI ≤3 (88% vs 67%; P <.0001). Conclusion: The age-adjusted CCI is a significant predictor of noncancer CSS and OS for patients with locally advanced laryngeal cancer but is not associated with DSS.

Original languageEnglish (US)
Pages (from-to)2060-2069
Number of pages10
JournalHead and Neck
Issue number9
StatePublished - Sep 2018


  • age
  • comorbidity
  • head and neck cancer
  • larynx cancer
  • radiotherapy
  • survival outcomes

ASJC Scopus subject areas

  • Otorhinolaryngology


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