@article{faed06388af942788c2737097d0c452c,
title = "Age-adjusted comorbidity and survival in locally advanced laryngeal cancer",
abstract = "Background: The purpose of this study was to quantify the relationship among age, pretreatment comorbidity, and survival outcomes in patients with locally advanced laryngeal cancer. Methods: Baseline comorbidity data were collected and age-adjusted Charlson Comorbidity Index (CCI) was calculated for each case. Kaplan-Meier and Cox proportional hazards modeling were used to determine associations with survival. Results: For 548 patients, with a median age of 59 years (range 31-91 years), 58% were treated with larynx preservation and the rest with total laryngectomy and adjuvant radiotherapy (RT). Two hundred thirty-eight patients (43%) had at least 1 comorbidity each. Cardiovascular diseases were the most common comorbidities (19%). The 5-year overall survival (OS) for patients with CCI ≤3 (n = 442) were superior to CCI >3 (n = 106; 60% vs 41%; P <.0001), although the 5-year disease-specific survival (DSS) rates were not significantly different. The 5-year noncancer CSS was better for age-adjusted CCI ≤3 (88% vs 67%; P <.0001). Conclusion: The age-adjusted CCI is a significant predictor of noncancer CSS and OS for patients with locally advanced laryngeal cancer but is not associated with DSS.",
keywords = "age, comorbidity, head and neck cancer, larynx cancer, radiotherapy, survival outcomes",
author = "{Multidisciplinary Larynx Cancer Working Group} and Mulcahy, {Collin F.} and Mohamed, {Abdallah S.R.} and Aasheesh Kanwar and Hutcheson, {Katherine A.} and Alokananda Ghosh and David Vock and Weber, {Randal S.} and Lai, {Stephen Y.} and Gunn, {Gary Brandon} and Mark Zafereo and Morrison, {William H.} and Renata Ferrarotto and Garden, {Adam S.} and Rosenthal, {David I.} and Fuller, {Clifton D.}",
note = "Funding Information: Drs Lai, Mohamed, and Fuller receive funding support from the National Institutes of Health (NIH)/National Institute for Dental and Craniofacial Research (1R01DE025248–01/ R56DE025248–01). Dr Fuller is a Sabin Family Foundation Fellow and receives grant and/or salary support from the NIH/National Cancer Institute (NCI) Head and Neck Specialized Programs of Research Excellence (SPORE) Developmental Research Program Award (P50CA097007–10) and Paul Calabresi Clinical Oncology Program Award (K12 CA088084–06); the National Science Foundation (NSF), Division of Mathematical Sciences, Joint NIH/NSF Initiative on Quantitative Approaches to Biomedical Big Data (QUBBD) Grant (NSF 1557679); the NCI QUBBD (1R01CA225190-01); the NIH Big Data to Knowledge (BD2K) Program of the National Cancer Institute (NCI) Early Stage Development of Technologies in Biomedical Computing, Informatics, and Big Data Science Award (1R01CA214825-01); NCI Early Phase Clinical Trials in Imaging and Image-Guided Interventions Program (1R01CA218148-01); a General Electric Healthcare/MD Anderson Center for Advanced Biomedical Imaging In-Kind Award; an Elekta AB/MD Anderson Department of Radiation Oncology Seed Grant; the Center for Radiation Oncology Research (CROR) at MD Anderson Cancer Center Seed Grant; and the MD Anderson Institutional Research Grant (IRG) Program. Dr Fuller has received speaker travel funding from Elekta AB. Supported in part by the National Institutes of Health (NIH)/National Cancer Institute (NCI) Cancer Center Support (Core) Grant CA016672 to The University of Texas MD Anderson Cancer Center. Funding Information: Drs Lai, Mohamed, and Fuller receive funding support from the National Institutes of Health (NIH)/National Institute for Dental and Craniofacial Research (1R01DE025248–01/R56DE025248–01). Dr Fuller is a Sabin Family Foundation Fellow and receives grant and/or salary support from the NIH/ National Cancer Institute (NCI) Head and Neck Specialized Programs of Research Excellence (SPORE) Developmental Research Program Award (P50CA097007–10) and Paul Calabresi Clinical Oncology Program Award (K12 CA088084–06); the National Science Foundation (NSF), Division of Mathematical Sciences, Joint NIH/NSF Initiative on Quantitative Approaches to Biomedical Big Data (QUBBD) Grant (NSF 1557679); the NCI QUBBD (1R01CA225190-01); the NIH Big Data to Knowledge (BD2K) Program of the National Cancer Institute (NCI) Early Stage Development of Technologies in Biomedical Computing, Informatics, and Big Data Science Award (1R01CA214825-01); NCI Early Phase Clinical Trials in Imaging and Image-Guided Interventions Program (1R01CA218148-01); a General Electric Healthcare/MD Anderson Center for Advanced Biomedical Imaging In-Kind Award; an Elekta AB/MD Anderson Department of Radiation Oncology Seed Grant; the Center for Radiation Oncology Research (CROR) at MD Anderson Cancer Center Seed Grant; and the MD Anderson Institutional Research Grant (IRG) Program. Dr Fuller has received speaker travel funding from Elekta AB. Supported in part by the National Institutes of Health (NIH)/National Cancer Institute (NCI) Cancer Center Support (Core) Grant CA016672 to The University of Texas MD Anderson Cancer Center Publisher Copyright: {\textcopyright} 2018 Wiley Periodicals, Inc.",
year = "2018",
month = sep,
doi = "10.1002/hed.25200",
language = "English (US)",
volume = "40",
pages = "2060--2069",
journal = "Head and Neck Surgery",
issn = "1043-3074",
publisher = "Wiley",
number = "9",
}