Agarose coating improves protein stability during sustained release

Enrica De Rosa, I. Yadzi, Xuewu Liu, Mauro Ferrari, Ennio Tasciotti

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Effectiveness of drug administration has been improved developing many organic systems to target the drug to a specific site and at a desired rate. Nevertheless most of them are rapidly eliminated by the reticulum endothelial system and are poorly stable. Biocompatible and biodegradable porous silicon microparticles can be loaded with bioactive molecules and superficially modified to provide controlled release. However, the stability of the loaded bioactive molecules has not been guaranteed so far. In this work we describe an agarose coating that provides long term protection of the bioactive molecule prior to its delivery thus assuring an effective protein uptake from the cells.

Original languageEnglish (US)
Title of host publicationNanotechnology 2010
Subtitle of host publicationBio Sensors, Instruments, Medical, Environment and Energy - Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010
Pages289-291
Number of pages3
StatePublished - 2010
EventNanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010 - Anaheim, CA, United States
Duration: Jun 21 2010Jun 24 2010

Publication series

NameNanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010
Volume3

Other

OtherNanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010
CountryUnited States
CityAnaheim, CA
Period6/21/106/24/10

Keywords

  • Coating
  • Drug delivery
  • Porous silicon
  • Protein stability

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering
  • Electrical and Electronic Engineering

Fingerprint Dive into the research topics of 'Agarose coating improves protein stability during sustained release'. Together they form a unique fingerprint.

Cite this