Advances in nanodelivery of green tea catechins to enhance the anticancer activity

Yike Jiang, Ziyi Jiang, Lan Ma, Qingrong Huang

Research output: Contribution to journalReview articlepeer-review

Abstract

Cancer is one of the leading causes of death globally. A variety of phenolic compounds display preventative and therapeutic effects against cancers. Green teas are rich in phenolics. Catechins are the most dominant phenolic component in green teas. Studies have shown that catechins have anticancer activity in various cancer models. The anticancer activity of catechins, however, may be compromised due to their low oral bioavailability. Nanodelivery emerges as a promising way to improve the oral bioavailability and anticancer activity of catechins. Research in this area has been actively conducted in recent decades. This review provides the molecular mechanisms of the anticancer effects of catechins, the factors that limit the oral bioavailability of catechins, and the latest advances of delivering catechins using nanodelivery systems through different routes to enhance their anticancer activity.

Original languageEnglish (US)
Article number3301
JournalMolecules
Volume26
Issue number11
DOIs
StatePublished - Jun 1 2021

Keywords

  • Anticancer activity
  • Catechins
  • Green tea
  • Nanodelivery system
  • Phenolic compounds

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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