Advances in Management of Pediatric Ependymomas

Frank Y. Lin, Murali Chintagumpala

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Ependymomas are a heterogeneous group of neuroepithelial tumors of children and adults. In pediatric cases, the standard of care has long consisted of neurosurgical resection to the greatest extent acceptable followed by adjuvant involved field irradiation. Complete macroscopic surgical resection has remained the only consistent clinical variable known to improve survival. Adjuvant chemotherapy has yet to predictably affect outcome, possibly due to the molecular heterogeneity of histologically similar tumors. The administration of chemotherapy subsequently remains limited to clinical trials. However, recent comprehensive genomic, transcriptomic, and epigenetic interrogations of ependymomas have uncovered unique molecular characteristics and subtypes that correlated with clinical features such as age, neuroanatomical location, and prognosis. These findings represent a potential paradigm shift and provide a biologic rationale for targeted therapeutic strategies and risk-adapted administration of conventional treatment modalities. In this review, we focus on intracranial WHO grade II and III ependymoma of children and discuss conventional management strategies, followed by recent biologic findings and novel therapeutics currently under investigation.

Original languageEnglish (US)
Article number47
JournalCurrent Oncology Reports
Volume17
Issue number10
DOIs
StatePublished - Oct 22 2015

Keywords

  • Molecular subtypes of ependymoma
  • Pediatric ependymoma
  • Prognostic factors in ependymoma
  • Radiation therapy for ependymoma

ASJC Scopus subject areas

  • Oncology

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