Advancements in Modeling Colorectal Cancer in Rodents

Huanhuan Joyce Chen; Yanan Zheng; Zhubo Wei

doi:10.1007/s11888-016-0334-5

Advancements in Modeling Colorectal Cancer in Rodents

Huanhuan Joyce Chen, Yanan Zheng, Zhubo Wei

Academic Institute

Research output: Contribution to journal › Review article › peer-review

Abstract

Colorectal cancer (CRC) has become a large burden on the health care system with 700,000 people dying from this disease annually in the world. Rodent cancer models, especially the mouse models, play critical roles in the understanding of CRC etiology and the development of CRC therapies. This review is focused on reporting the significant progress that has been made in CRC studies using transplant models and forward genetics mouse models. Rat CRC models are also described as they were usually skipped in other related reviews. We also try to discuss what needs to be improved in rodent model studies to better serve as the CRC research tools and preclinical models for patient care and treatments.

Original language	English (US)
Pages (from-to)	274-280
Number of pages	7
Journal	Current Colorectal Cancer Reports
Volume	12
Issue number	5
DOIs	https://doi.org/10.1007/s11888-016-0334-5
State	Published - Oct 1 2016

Keywords

Colorectal cancer
GEM models
Metastatic models
Organoid xenograft
Orthotopic xenograft
Patient-derived xenograft
Rat CRC models
Transposon insertional mutagenesis

ASJC Scopus subject areas

Hepatology
Oncology
Gastroenterology

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10.1007/s11888-016-0334-5

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title = "Advancements in Modeling Colorectal Cancer in Rodents",

abstract = "Colorectal cancer (CRC) has become a large burden on the health care system with 700,000 people dying from this disease annually in the world. Rodent cancer models, especially the mouse models, play critical roles in the understanding of CRC etiology and the development of CRC therapies. This review is focused on reporting the significant progress that has been made in CRC studies using transplant models and forward genetics mouse models. Rat CRC models are also described as they were usually skipped in other related reviews. We also try to discuss what needs to be improved in rodent model studies to better serve as the CRC research tools and preclinical models for patient care and treatments.",

keywords = "Colorectal cancer, GEM models, Metastatic models, Organoid xenograft, Orthotopic xenograft, Patient-derived xenograft, Rat CRC models, Transposon insertional mutagenesis",

author = "Chen, {Huanhuan Joyce} and Yanan Zheng and Zhubo Wei",

note = "Funding Information: This work was supported by NCI-PSOC Young Investigator trans-network grant (to H.J.C and Z.W.) and Arnold O. Beckman Postdoctoral fellowship (to H.J.C). Publisher Copyright: {\textcopyright} 2016, Springer Science+Business Media New York. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "2016",

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doi = "10.1007/s11888-016-0334-5",

language = "English (US)",

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T1 - Advancements in Modeling Colorectal Cancer in Rodents

AU - Chen, Huanhuan Joyce

AU - Zheng, Yanan

AU - Wei, Zhubo

N1 - Funding Information: This work was supported by NCI-PSOC Young Investigator trans-network grant (to H.J.C and Z.W.) and Arnold O. Beckman Postdoctoral fellowship (to H.J.C). Publisher Copyright: © 2016, Springer Science+Business Media New York. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Colorectal cancer (CRC) has become a large burden on the health care system with 700,000 people dying from this disease annually in the world. Rodent cancer models, especially the mouse models, play critical roles in the understanding of CRC etiology and the development of CRC therapies. This review is focused on reporting the significant progress that has been made in CRC studies using transplant models and forward genetics mouse models. Rat CRC models are also described as they were usually skipped in other related reviews. We also try to discuss what needs to be improved in rodent model studies to better serve as the CRC research tools and preclinical models for patient care and treatments.

AB - Colorectal cancer (CRC) has become a large burden on the health care system with 700,000 people dying from this disease annually in the world. Rodent cancer models, especially the mouse models, play critical roles in the understanding of CRC etiology and the development of CRC therapies. This review is focused on reporting the significant progress that has been made in CRC studies using transplant models and forward genetics mouse models. Rat CRC models are also described as they were usually skipped in other related reviews. We also try to discuss what needs to be improved in rodent model studies to better serve as the CRC research tools and preclinical models for patient care and treatments.

KW - Colorectal cancer

KW - GEM models

KW - Metastatic models

KW - Organoid xenograft

KW - Orthotopic xenograft

KW - Patient-derived xenograft

KW - Rat CRC models

KW - Transposon insertional mutagenesis

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U2 - 10.1007/s11888-016-0334-5

DO - 10.1007/s11888-016-0334-5

M3 - Review article

AN - SCOPUS:84982942896

SN - 1556-3790

VL - 12

SP - 274

EP - 280

JO - Current Colorectal Cancer Reports

JF - Current Colorectal Cancer Reports

IS - 5

ER -

Advancements in Modeling Colorectal Cancer in Rodents

Abstract

Keywords

ASJC Scopus subject areas

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