Advancements in Modeling Colorectal Cancer in Rodents

Huanhuan Joyce Chen, Yanan Zheng, Zhubo Wei

Research output: Contribution to journalReview article

Abstract

Colorectal cancer (CRC) has become a large burden on the health care system with 700,000 people dying from this disease annually in the world. Rodent cancer models, especially the mouse models, play critical roles in the understanding of CRC etiology and the development of CRC therapies. This review is focused on reporting the significant progress that has been made in CRC studies using transplant models and forward genetics mouse models. Rat CRC models are also described as they were usually skipped in other related reviews. We also try to discuss what needs to be improved in rodent model studies to better serve as the CRC research tools and preclinical models for patient care and treatments.

Original languageEnglish (US)
Pages (from-to)274-280
Number of pages7
JournalCurrent Colorectal Cancer Reports
Volume12
Issue number5
DOIs
StatePublished - Oct 1 2016

Keywords

  • Colorectal cancer
  • GEM models
  • Metastatic models
  • Organoid xenograft
  • Orthotopic xenograft
  • Patient-derived xenograft
  • Rat CRC models
  • Transposon insertional mutagenesis

ASJC Scopus subject areas

  • Hepatology
  • Oncology
  • Gastroenterology

Fingerprint Dive into the research topics of 'Advancements in Modeling Colorectal Cancer in Rodents'. Together they form a unique fingerprint.

Cite this