TY - JOUR
T1 - Advancements in Modeling Colorectal Cancer in Rodents
AU - Chen, Huanhuan Joyce
AU - Zheng, Yanan
AU - Wei, Zhubo
N1 - Funding Information:
This work was supported by NCI-PSOC Young Investigator trans-network grant (to H.J.C and Z.W.) and Arnold O. Beckman Postdoctoral fellowship (to H.J.C).
Publisher Copyright:
© 2016, Springer Science+Business Media New York.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Colorectal cancer (CRC) has become a large burden on the health care system with 700,000 people dying from this disease annually in the world. Rodent cancer models, especially the mouse models, play critical roles in the understanding of CRC etiology and the development of CRC therapies. This review is focused on reporting the significant progress that has been made in CRC studies using transplant models and forward genetics mouse models. Rat CRC models are also described as they were usually skipped in other related reviews. We also try to discuss what needs to be improved in rodent model studies to better serve as the CRC research tools and preclinical models for patient care and treatments.
AB - Colorectal cancer (CRC) has become a large burden on the health care system with 700,000 people dying from this disease annually in the world. Rodent cancer models, especially the mouse models, play critical roles in the understanding of CRC etiology and the development of CRC therapies. This review is focused on reporting the significant progress that has been made in CRC studies using transplant models and forward genetics mouse models. Rat CRC models are also described as they were usually skipped in other related reviews. We also try to discuss what needs to be improved in rodent model studies to better serve as the CRC research tools and preclinical models for patient care and treatments.
KW - Colorectal cancer
KW - GEM models
KW - Metastatic models
KW - Organoid xenograft
KW - Orthotopic xenograft
KW - Patient-derived xenograft
KW - Rat CRC models
KW - Transposon insertional mutagenesis
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U2 - 10.1007/s11888-016-0334-5
DO - 10.1007/s11888-016-0334-5
M3 - Review article
AN - SCOPUS:84982942896
SN - 1556-3790
VL - 12
SP - 274
EP - 280
JO - Current Colorectal Cancer Reports
JF - Current Colorectal Cancer Reports
IS - 5
ER -