Advanced strategies in immune modulation of cancer using lipid-based nanoparticles

Shoshy Mizrahy, Inbal Hazan-Halevy, Dalit Landesman-Milo, Brandon D. Ng, Dan Peer

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Immunotherapy has a great potential in advancing cancer treatment, especially in light of recent discoveries and therapeutic interventions that lead to complete response in specific subgroups of melanoma patients. By using the body's own immune system, it is possible not only to specifically target and eliminate cancer cells while leaving healthy cells unharmed but also to elicit long-term protective response. Despite the promise, current immunotherapy is limited and fails in addressing all tumor types. This is probably due to the fact that a single treatment strategy is not sufficient in overcoming the complex antitumor immunity. The use of nanoparticle-based system for immunotherapy is a promising strategy that can simultaneously target multiple pathways with the same kinetics to enhance antitumor response. Here, we will highlight the recent advances in the field of cancer immunotherapy that utilize lipid-based nanoparticles as delivery vehicles and address the ongoing challenges and potential opportunities.

Original languageEnglish (US)
Article number69
JournalFrontiers in immunology
Volume8
Issue numberFEB
DOIs
StatePublished - Feb 6 2017

Keywords

  • Cancer immunotherapy
  • Cancer vaccines
  • Lipid nanoparticles
  • SiRNA therapeutic
  • Tumor microenvironment

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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