Adrenal Cortical Carcinoma-Review of Current Knowledge and Treatment Practices

Alexandria T. Phan

Research output: Contribution to journalReview article

35 Scopus citations

Abstract

Adrenal cortical carcinoma is a rare endocrine malignancy with a poor long-term prognosis. Accurate diagnosis and preoperative evaluation of the patient presenting with an adrenal mass maximize the opportunity for optimal treatment planning. Surgery still offers the best chance for cure. Despite curability with complete surgical resection, the rate of recurrence is unacceptably high. In metastatic or recurrent disease, systemic treatment options are limited to chemotherapy with or without mitotane. Therapeutic options are often outdated and associated with significant toxicities. A multidisciplinary approach has the best chance for offering optimized management of this lethal disease. Improved understanding of the molecular pathogenesis of this rare malignancy will lead to advancement in the available therapies that may improve this outcome.

Original languageEnglish (US)
Pages (from-to)489-507
Number of pages19
JournalHematology/Oncology Clinics of North America
Volume21
Issue number3
DOIs
StatePublished - Jun 2007

ASJC Scopus subject areas

  • Hematology
  • Oncology

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