Adoptive T cell therapy of cancer

Research output: Contribution to journalReview article

94 Scopus citations

Abstract

Adoptive transfer of T cells specific for antigens expressed on tumor cells is an attractive strategy for producing targeted and long-lived anti-tumor activity. T cell therapies have shown activity in selected clinical applications but broader application is limited by inadequate persistence of transferred T cells and by tumor-evasion strategies. Current research focuses on defining the optimum type of cell for transfer, genetically modifying infused T cells to augment function and overcome tumor evasion strategies and modulating the host environment.

Original languageEnglish (US)
Pages (from-to)251-257
Number of pages7
JournalCurrent Opinion in Immunology
Volume22
Issue number2
DOIs
StatePublished - Apr 2010

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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