Adoptive immunotherapy for posttransplantation viral infections

Catherine M. Bollard, Ingrid Kuehnle, Ann Leen, Cliona M. Rooney, Helen E. Heslop

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

Viral diseases are a major cause of morbidity and mortality after hemopoietic stem cell transplantation. Because viral complications in these patients are clearly associated with the lack of recovery of virus-specific cellular immune responses, reconstitution of the host with in vitro expanded cytotoxic T lymphocytes is a potential approach to prevent and treat these diseases. Initial clinical studies of cytomegalovirus and Epstein-Barr virus in human stem cell transplant patients have shown that adoptively transferred donor-derived virus-specific T cells may restore protective immunity and control established infections. Preclinical studies are evaluating this approach for other viruses while strategies for generating T cells specific for multiple viruses to provide broader protection are being evaluated in clinical trials. The use of genetically modified T cells or the use of newer suicide genes may result in improved safety and efficacy.

Original languageEnglish (US)
Pages (from-to)143-155
Number of pages13
JournalBiology of Blood and Marrow Transplantation
Volume10
Issue number3
DOIs
StatePublished - Mar 2004

Keywords

  • Immunotherapy
  • Stem cell transplantation
  • Viral infection

ASJC Scopus subject areas

  • Transplantation

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