Adolescent Tuberculosis Associated with Tuberculosis Exposure in Classrooms and Dorm Rooms in Guangxi, China

Dongxiang Pan, Rushu Lan, Edward A Graviss, Dingwen Lin, Dabin Liang, Edward McNeil, Mei Lin, Virasakdi Chongsuvivatwong

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

OBJECTIVE: Quantify tuberculosis (TB) risk attributable to dorm room exposure in addition to classroom exposure.

METHODS: Adolescent school contact investigations were conducted for every reported index TB case, and similar contact investigations were conducted in selected community-control classes from November 2016 to October 2017 in Guangxi, China.

RESULTS: A total of 6263 contacts of 112 index TB cases and 6130 classmates of 112 controls were investigated. There were 14, 12 and 2 new active TB cases detected among classmates/non-roommates of index cases, classmates/roommates of index cases and control classmates, respectively. Compared with control contacts, the adjusted relative risk (95% confidence interval (CI)) and population attributable fraction (PAF) for being a classmate/non-roommate of the index case increased the risk of active TB diagnosis to 8.44 (95% CI: 1.31-54.48) and 44.1%. The adjusted RR and PAF for being a classmate/roommate of the index case was 29.37 (95% CI: 3.80, 227.11) and 41.4%. Being classmates/roommates significantly increased the risk of TB compared to a classmate/non-roommate of the index case (RR=3.48, 95% CI: 1.64, 7.40).

CONCLUSION: The additional risk of TB due to exposure in the dorm room should be taken into account in planning of TB prevention and control in boarding schools.

Original languageEnglish (US)
JournalInternational Journal of Infectious Diseases
DOIs
StateE-pub ahead of print - Sep 26 2018

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