Administration of antibody to the lung protects mice against pneumonic plague

Jim Hill; Jim E. Eyles; Stephen J. Elvin; Gareth D. Healey; Roman A. Lukaszewski; Richard W. Titball

doi:10.1128/IAI.74.5.3068-3070.2006

Administration of antibody to the lung protects mice against pneumonic plague

Jim Hill, Jim E. Eyles, Stephen J. Elvin, Gareth D. Healey, Roman A. Lukaszewski, Richard W. Titball

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Intratracheal delivery of aerosolized monoclonal antibodies with specificity for Yersinia pestis LcrV and F1 antigens protected mice in a model of pneumonic plague. These data support the utility of inhaled antibodies as a fast-acting postexposure treatment for plague.

Original language	English (US)
Pages (from-to)	3068-3070
Number of pages	3
Journal	Infection and Immunity
Volume	74
Issue number	5
DOIs	https://doi.org/10.1128/IAI.74.5.3068-3070.2006
State	Published - May 2006

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Infectious Diseases

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10.1128/IAI.74.5.3068-3070.2006

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title = "Administration of antibody to the lung protects mice against pneumonic plague",

abstract = "Intratracheal delivery of aerosolized monoclonal antibodies with specificity for Yersinia pestis LcrV and F1 antigens protected mice in a model of pneumonic plague. These data support the utility of inhaled antibodies as a fast-acting postexposure treatment for plague.",

author = "Jim Hill and Eyles, {Jim E.} and Elvin, {Stephen J.} and Healey, {Gareth D.} and Lukaszewski, {Roman A.} and Titball, {Richard W.}",

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AU - Elvin, Stephen J.

AU - Healey, Gareth D.

AU - Lukaszewski, Roman A.

AU - Titball, Richard W.

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AB - Intratracheal delivery of aerosolized monoclonal antibodies with specificity for Yersinia pestis LcrV and F1 antigens protected mice in a model of pneumonic plague. These data support the utility of inhaled antibodies as a fast-acting postexposure treatment for plague.

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JO - Infection and Immunity

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Administration of antibody to the lung protects mice against pneumonic plague

Abstract

ASJC Scopus subject areas

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