Administration of antibody to the lung protects mice against pneumonic plague

Jim Hill, Jim E. Eyles, Stephen J. Elvin, Gareth D. Healey, Roman A. Lukaszewski, Richard W. Titball

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

Intratracheal delivery of aerosolized monoclonal antibodies with specificity for Yersinia pestis LcrV and F1 antigens protected mice in a model of pneumonic plague. These data support the utility of inhaled antibodies as a fast-acting postexposure treatment for plague.

Original languageEnglish (US)
Pages (from-to)3068-3070
Number of pages3
JournalInfection and Immunity
Volume74
Issue number5
DOIs
StatePublished - May 2006

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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