Adjuncts to mechanical ventilation in ARDS

James E Lynch, J Mark Cheek, Edward Y Chan, Joseph B Zwischenberger

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Since its first description, acute respiratory distress syndrome has been characterized by abnormal physiologic and gas exchange properties of the lungs. Many adjunctive therapies have been developed to reduce the stresses of mechanical ventilation on already damaged lungs. We examined the mechanism of action and the latest clinical trial information of several adjunctive therapies including prone positioning, nitric oxide, extracorporeal membrane oxygenation, arterial venous carbon dioxide removal, and liquid ventilation. While all of these therapies have demonstrated short-term improvements in arterial blood gases and in the limitation of lung injury, none have shown an evidence-based survival benefit.

Original languageEnglish (US)
Pages (from-to)20-7
Number of pages8
JournalSeminars in Thoracic and Cardiovascular Surgery
Issue number1
StatePublished - 2006


  • Carbon Dioxide
  • Extracorporeal Circulation
  • Extracorporeal Membrane Oxygenation
  • Humans
  • Liquid Ventilation
  • Nitric Oxide
  • Prone Position
  • Pulmonary Gas Exchange
  • Pulmonary Surfactants
  • Respiration, Artificial
  • Respiratory Distress Syndrome, Adult
  • Tidal Volume
  • Journal Article
  • Review


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