Adjunctive Clavulanic Acid Abolishes the Cefazolin Inoculum Effect in an Experimental Rat Model of Methicillin-Sensitive Staphylococcus aureus Endocarditis

William R. Miller, Kavindra Singh, Cesar A. Arias, Barbara E. Murray

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

We tested the ability of clavulanic acid to restore the efficacy of cefazolin against Staphylococcus aureus TX0117, which exhibits the cefazolin inoculum effect (CzIE). In the rat infective endocarditis model, the coadministration of cefazolin plus clavulanic acid resulted in a significant reduction of bacterial counts (7.1 0.5 log10 CFU/g) compared to that with cefazolin alone (2 0.6 log10 CFU/g; P 0.0001). The addition of a -lactamase inhibitor may be a viable strategy for overcoming the CzIE.

Original languageEnglish (US)
Article numbere01158-18
JournalAntimicrobial Agents and Chemotherapy
Volume62
Issue number11
DOIs
StatePublished - Nov 2018

Keywords

  • Animal models
  • Cefazolin
  • Clavulanic acid
  • Infective endocarditis
  • Inoculum effect
  • Staphylococcus aureus

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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