Abstract
A rodent model was used to study tissue expansion. Three chemical agents - hyaluronidase, prostaglandin E2 and colchicine - were administered and their effects on tissue expansion studied. Hyaluronidase and colchicine both enhanced the rate of expansion when compared with results in control animals (p < 0.05). Although prostaglandin E2 had less effect on expansion rate, it did significantly enhance tissue oxygen tension of expanded skin when compared with controls (p < 0.05). Clinical implications include the possibility of pretreating patients with these agents to increase the rate of expansion and to improve the safety of current methods of expansion.
Original language | English (US) |
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Pages (from-to) | 412-416 |
Number of pages | 5 |
Journal | Annals of plastic surgery |
Volume | 23 |
Issue number | 5 |
DOIs | |
State | Published - Jan 1 1989 |
ASJC Scopus subject areas
- Surgery