Adhesion of microfabricated particles on vascular endothelium: A parametric analysis

Paolo Decuzzi, Stephen Lee, Marco Decuzzi, Mauro Ferrari

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

"Smart" drug delivery systems should be selective and effective to ensure drug administration at the right time, at the right dosage, and anywhere in the body. Among the several administration routes and delivery systems that have been proposed, one of the most effective and promising is based on microfabricated particles injected directly into the blood stream. The shape, size, and material properties of the particles can be designed and optimized depending on the specific applications and targets (cell, tissue, or circulating virus). Since the binding affinity of particles to cells is affected by both the binding force and its growth rate with time, 5 it is of great importance to consider the viscous response of the system. In this work, a parametric analysis is presented where the probability of adhesion of a microfabricated particle on the endothelium is expressed as a function of (i) the hemodynamic conditions, (ii) the viscoelastic properties of the particle and targeted cell, and (iii) density of ligands grafted over the particle. Criteria for the optimal design of particles are proposed.

Original languageEnglish (US)
Pages (from-to)793-802
Number of pages10
JournalAnnals of Biomedical Engineering
Volume32
Issue number6
DOIs
StatePublished - Jun 1 2004

Keywords

  • Adhesion probability
  • Drug delivery systems
  • Viscoelasticity

ASJC Scopus subject areas

  • Biomedical Engineering

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