TY - JOUR
T1 - Adhesion of microfabricated particles on vascular endothelium
T2 - A parametric analysis
AU - Decuzzi, Paolo
AU - Lee, Stephen
AU - Decuzzi, Marco
AU - Ferrari, Mauro
N1 - Funding Information:
Sincere thanks are due to the referees whose constructive comments helped to improve this paper. Dr. Paolo Decuzzi acknowledges financial support from the Center of Excellence for Computational Mechanics at the Politecnico di Bari – Italy.
Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2004/6
Y1 - 2004/6
N2 - "Smart" drug delivery systems should be selective and effective to ensure drug administration at the right time, at the right dosage, and anywhere in the body. Among the several administration routes and delivery systems that have been proposed, one of the most effective and promising is based on microfabricated particles injected directly into the blood stream. The shape, size, and material properties of the particles can be designed and optimized depending on the specific applications and targets (cell, tissue, or circulating virus). Since the binding affinity of particles to cells is affected by both the binding force and its growth rate with time, 5 it is of great importance to consider the viscous response of the system. In this work, a parametric analysis is presented where the probability of adhesion of a microfabricated particle on the endothelium is expressed as a function of (i) the hemodynamic conditions, (ii) the viscoelastic properties of the particle and targeted cell, and (iii) density of ligands grafted over the particle. Criteria for the optimal design of particles are proposed.
AB - "Smart" drug delivery systems should be selective and effective to ensure drug administration at the right time, at the right dosage, and anywhere in the body. Among the several administration routes and delivery systems that have been proposed, one of the most effective and promising is based on microfabricated particles injected directly into the blood stream. The shape, size, and material properties of the particles can be designed and optimized depending on the specific applications and targets (cell, tissue, or circulating virus). Since the binding affinity of particles to cells is affected by both the binding force and its growth rate with time, 5 it is of great importance to consider the viscous response of the system. In this work, a parametric analysis is presented where the probability of adhesion of a microfabricated particle on the endothelium is expressed as a function of (i) the hemodynamic conditions, (ii) the viscoelastic properties of the particle and targeted cell, and (iii) density of ligands grafted over the particle. Criteria for the optimal design of particles are proposed.
KW - Adhesion probability
KW - Drug delivery systems
KW - Viscoelasticity
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U2 - 10.1023/B:ABME.0000030255.36748.d3
DO - 10.1023/B:ABME.0000030255.36748.d3
M3 - Article
C2 - 15255210
AN - SCOPUS:3242715145
VL - 32
SP - 793
EP - 802
JO - Annals of Biomedical Engineering
JF - Annals of Biomedical Engineering
SN - 0090-6964
IS - 6
ER -