Adhesion of astrocytes to charge modified silicon substrates

W. Shain; H. Ancin; Harold G. Craighead; M. Isaacson; L. C. Kam; B. Roysam; D. Szarowski; J. N. Turner; S. W. Turner

Adhesion of astrocytes to charge modified silicon substrates

W. Shain, H. Ancin, Harold G. Craighead, M. Isaacson, L. C. Kam, B. Roysam, D. Szarowski, J. N. Turner, S. W. Turner

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Chemical modifications to the surface of the probe may improve integration into host tissues by preventing sheath development, and may promote directed connections between the thin film electrodes (TFEs) and neurons. The used of positively charged molecules to promote adhesion of astrocytes onto silicon surfaces are examined. Double staining with acriflavin and diIC₁₈ allowed visualization of cell nuclei, cell membranes, and the octadecyltrichlorosilane (OTS) background. Scanning laser confocal microscopy is used to collect three dimensional digital images. An automated cell counting program is used to localize the position of the OTS background to determine how many cells adhered to the charged pattern versus the unchanged background.

Original language	English
Title of host publication	Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium
Editors	Anon
Place of Publication	St. Louis Park, MN, United States
Publisher	Soc for Biomaterials
Volume	1
State	Published - Dec 1 1996
Event	Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can Duration: May 29 1996 → Jun 2 1996

Other

Other	Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
City	Toronto, Can
Period	5/29/96 → 6/2/96

ASJC Scopus subject areas

Materials Science(all)

Cite this

Adhesion of astrocytes to charge modified silicon substrates. / Shain, W.; Ancin, H.; Craighead, Harold G. et al.

Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. ed. / Anon. Vol. 1 St. Louis Park, MN, United States : Soc for Biomaterials, 1996.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Shain, W, Ancin, H, Craighead, HG, Isaacson, M, Kam, LC, Roysam, B, Szarowski, D, Turner, JN & Turner, SW 1996, Adhesion of astrocytes to charge modified silicon substrates. in Anon (ed.), Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. vol. 1, Soc for Biomaterials, St. Louis Park, MN, United States, Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2), Toronto, Can, 5/29/96.

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abstract = "Chemical modifications to the surface of the probe may improve integration into host tissues by preventing sheath development, and may promote directed connections between the thin film electrodes (TFEs) and neurons. The used of positively charged molecules to promote adhesion of astrocytes onto silicon surfaces are examined. Double staining with acriflavin and diIC18 allowed visualization of cell nuclei, cell membranes, and the octadecyltrichlorosilane (OTS) background. Scanning laser confocal microscopy is used to collect three dimensional digital images. An automated cell counting program is used to localize the position of the OTS background to determine how many cells adhered to the charged pattern versus the unchanged background.",

author = "W. Shain and H. Ancin and Craighead, {Harold G.} and M. Isaacson and Kam, {L. C.} and B. Roysam and D. Szarowski and Turner, {J. N.} and Turner, {S. W.}",

year = "1996",

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language = "English",

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editor = "Anon",

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T1 - Adhesion of astrocytes to charge modified silicon substrates

AU - Shain, W.

AU - Ancin, H.

AU - Craighead, Harold G.

AU - Isaacson, M.

AU - Kam, L. C.

AU - Roysam, B.

AU - Szarowski, D.

AU - Turner, J. N.

AU - Turner, S. W.

PY - 1996/12/1

Y1 - 1996/12/1

N2 - Chemical modifications to the surface of the probe may improve integration into host tissues by preventing sheath development, and may promote directed connections between the thin film electrodes (TFEs) and neurons. The used of positively charged molecules to promote adhesion of astrocytes onto silicon surfaces are examined. Double staining with acriflavin and diIC18 allowed visualization of cell nuclei, cell membranes, and the octadecyltrichlorosilane (OTS) background. Scanning laser confocal microscopy is used to collect three dimensional digital images. An automated cell counting program is used to localize the position of the OTS background to determine how many cells adhered to the charged pattern versus the unchanged background.

AB - Chemical modifications to the surface of the probe may improve integration into host tissues by preventing sheath development, and may promote directed connections between the thin film electrodes (TFEs) and neurons. The used of positively charged molecules to promote adhesion of astrocytes onto silicon surfaces are examined. Double staining with acriflavin and diIC18 allowed visualization of cell nuclei, cell membranes, and the octadecyltrichlorosilane (OTS) background. Scanning laser confocal microscopy is used to collect three dimensional digital images. An automated cell counting program is used to localize the position of the OTS background to determine how many cells adhered to the charged pattern versus the unchanged background.

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M3 - Conference contribution

AN - SCOPUS:0030413201

VL - 1

BT - Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium

A2 - Anon, null

PB - Soc for Biomaterials

CY - St. Louis Park, MN, United States

Y2 - 29 May 1996 through 2 June 1996

ER -

Adhesion of astrocytes to charge modified silicon substrates

Abstract

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ASJC Scopus subject areas

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