Adhesion of astrocytes to charge modified silicon substrates

W. Shain, H. Ancin, Harold G. Craighead, M. Isaacson, L. C. Kam, B. Roysam, D. Szarowski, J. N. Turner, S. W. Turner

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Chemical modifications to the surface of the probe may improve integration into host tissues by preventing sheath development, and may promote directed connections between the thin film electrodes (TFEs) and neurons. The used of positively charged molecules to promote adhesion of astrocytes onto silicon surfaces are examined. Double staining with acriflavin and diIC18 allowed visualization of cell nuclei, cell membranes, and the octadecyltrichlorosilane (OTS) background. Scanning laser confocal microscopy is used to collect three dimensional digital images. An automated cell counting program is used to localize the position of the OTS background to determine how many cells adhered to the charged pattern versus the unchanged background.

Original languageEnglish
Title of host publicationTransactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium
Editors Anon
Place of PublicationSt. Louis Park, MN, United States
PublisherSoc for Biomaterials
Volume1
StatePublished - Dec 1 1996
EventProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can
Duration: May 29 1996Jun 2 1996

Other

OtherProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
CityToronto, Can
Period5/29/966/2/96

ASJC Scopus subject areas

  • Materials Science(all)

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