Adherence to pharmacological interventions: Current trends and future directions

Shellie Ellis; Sally Shumaker; William Sieber; Cynthia Rand; Roger Anderson; Mary Benes-Malone; Stuart Cohen; Gail Crowley; Beth Dugan; Jacqueline Dunbar-Jacob; Deborah Farmer; Betty Kreuziger; Janet Lawrence; Wendy McBee; Paige McDonald; Carol Murphy; Linda Nyquist; Marcia Ory; Christin De La Paz; Mary Ann Sevick; Melissa Swaim; Perla Vargas; Kathleen Weeks; Linda Wieclaw

doi:10.1016/s0197-2456(00)00082-9

Adherence to pharmacological interventions: Current trends and future directions

Shellie Ellis, Sally Shumaker, William Sieber, Cynthia Rand, Roger Anderson, Mary Benes-Malone, Stuart Cohen, Gail Crowley, Beth Dugan, Jacqueline Dunbar-Jacob, Deborah Farmer, Betty Kreuziger, Janet Lawrence, Wendy McBee, Paige McDonald, Carol Murphy, Linda Nyquist, Marcia Ory, Christin De La Paz, Mary Ann SevickMelissa Swaim, Perla Vargas, Kathleen Weeks, Linda Wieclaw

Academic Institute

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

The complexity of adherence to pharmacological interventions is frequently underestimated. Consequently, little research has been done to understand, improve, or evaluate the effects of adherence to drug protocols. While efforts to better measure and increase adherence require dedicated resources, improved adherence in existing clinical research can potentially cut costs in trial size and length. This paper outlines strategies to facilitate research on adherence to pharmacological interventions including: reporting of adherence data, changing how we conceptualize adherence to pharmaceuticals, understanding issues unique to older adults' pill-taking behavior, and creating standardized methodologies to measure adherence. Further, we describe some promising research areas that may lead to effective interventions: adherence 'typologies' and modality matching. Control Clin Trials 2000;21:218S-225S Copyright (C) 2000 Elsevier Science Inc.

Original language	English (US)
Pages (from-to)	S218-S225
Journal	Controlled Clinical Trials
Volume	21
Issue number	5 SUPPL. 1
DOIs	https://doi.org/10.1016/s0197-2456(00)00082-9
State	Published - Dec 2000

Keywords

Clinical trials
Drugs
Geriatrics
Patient adherence

ASJC Scopus subject areas

Pharmacology

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10.1016/s0197-2456(00)00082-9

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Ellis, S., Shumaker, S., Sieber, W., Rand, C., Anderson, R., Benes-Malone, M., Cohen, S., Crowley, G., Dugan, B., Dunbar-Jacob, J., Farmer, D., Kreuziger, B., Lawrence, J., McBee, W., McDonald, P., Murphy, C., Nyquist, L., Ory, M., De La Paz, C., ... Wieclaw, L. (2000). Adherence to pharmacological interventions: Current trends and future directions. Controlled Clinical Trials, 21(5 SUPPL. 1), S218-S225. https://doi.org/10.1016/s0197-2456(00)00082-9

Ellis, S, Shumaker, S, Sieber, W, Rand, C, Anderson, R, Benes-Malone, M, Cohen, S, Crowley, G, Dugan, B, Dunbar-Jacob, J, Farmer, D, Kreuziger, B, Lawrence, J, McBee, W, McDonald, P, Murphy, C, Nyquist, L, Ory, M, De La Paz, C, Sevick, MA, Swaim, M, Vargas, P, Weeks, K & Wieclaw, L 2000, 'Adherence to pharmacological interventions: Current trends and future directions', Controlled Clinical Trials, vol. 21, no. 5 SUPPL. 1, pp. S218-S225. https://doi.org/10.1016/s0197-2456(00)00082-9

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abstract = "The complexity of adherence to pharmacological interventions is frequently underestimated. Consequently, little research has been done to understand, improve, or evaluate the effects of adherence to drug protocols. While efforts to better measure and increase adherence require dedicated resources, improved adherence in existing clinical research can potentially cut costs in trial size and length. This paper outlines strategies to facilitate research on adherence to pharmacological interventions including: reporting of adherence data, changing how we conceptualize adherence to pharmaceuticals, understanding issues unique to older adults' pill-taking behavior, and creating standardized methodologies to measure adherence. Further, we describe some promising research areas that may lead to effective interventions: adherence 'typologies' and modality matching. Control Clin Trials 2000;21:218S-225S Copyright (C) 2000 Elsevier Science Inc.",

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AU - Sevick, Mary Ann

AU - Swaim, Melissa

AU - Vargas, Perla

AU - Weeks, Kathleen

AU - Wieclaw, Linda

N1 - Funding Information: Funding for the conference from which this paper evolved and for postconference publication was provided by Merck & Co., Inc., National Institute on Aging (1R13AG16229-01), NIH Office of Behavioral and Social Science Research, and Wyeth-Ayerst Laboratories. Additional support was provided by the Women's Health Center of Excellence (DHHS 282-97-0025) and the Claude D. Pepper Older Americans Independence Center (NIH P60 AG10484).

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Adherence to pharmacological interventions: Current trends and future directions

Abstract

Keywords

ASJC Scopus subject areas

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