Adherence to pharmacological interventions: Current trends and future directions

Shellie Ellis, Sally Shumaker, William Sieber, Cynthia Rand, Roger Anderson, Mary Benes-Malone, Stuart Cohen, Gail Crowley, Beth Dugan, Jacqueline Dunbar-Jacob, Deborah Farmer, Betty Kreuziger, Janet Lawrence, Wendy McBee, Paige McDonald, Carol Murphy, Linda Nyquist, Marcia Ory, Christin De La Paz, Mary Ann SevickMelissa Swaim, Perla Vargas, Kathleen Weeks, Linda Wieclaw

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


The complexity of adherence to pharmacological interventions is frequently underestimated. Consequently, little research has been done to understand, improve, or evaluate the effects of adherence to drug protocols. While efforts to better measure and increase adherence require dedicated resources, improved adherence in existing clinical research can potentially cut costs in trial size and length. This paper outlines strategies to facilitate research on adherence to pharmacological interventions including: reporting of adherence data, changing how we conceptualize adherence to pharmaceuticals, understanding issues unique to older adults' pill-taking behavior, and creating standardized methodologies to measure adherence. Further, we describe some promising research areas that may lead to effective interventions: adherence 'typologies' and modality matching. Control Clin Trials 2000;21:218S-225S Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)S218-S225
JournalControlled Clinical Trials
Issue number5 SUPPL. 1
StatePublished - Dec 2000


  • Clinical trials
  • Drugs
  • Geriatrics
  • Patient adherence

ASJC Scopus subject areas

  • Pharmacology


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