Adenoid cystic carcinoma of the nasal cavity and paranasal sinuses: A meta-analysis

Moran Amit; Yoav Binenbaum; Kanika Sharma; Ramer Naomi; Ramer Ilana; Agbetoba Abib; Brett Miles; Xinjie Yang; Delin Lei; Bjoerndal Kristine; Godballe Christian; Mücke Thomas; Wolff Klaus-Dietrich; Dan Fliss; André M. Eckardt; Copelli Chiara; Enrico Sesenna; Palmer Frank; Snehal Patel; Ziv Gil

doi:10.1055/s-0033-1347358

Adenoid cystic carcinoma of the nasal cavity and paranasal sinuses: A meta-analysis

Moran Amit, Yoav Binenbaum, Kanika Sharma, Ramer Naomi, Ramer Ilana, Agbetoba Abib, Brett Miles, Xinjie Yang, Delin Lei, Bjoerndal Kristine, Godballe Christian, Mücke Thomas, Wolff Klaus-Dietrich, Dan Fliss, André M. Eckardt, Copelli Chiara, Enrico Sesenna, Palmer Frank, Snehal Patel, Ziv Gil

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

Objectives To identify independent predictors of outcome in patients with adenoid cystic carcinoma (ACC) of the paranasal sinuses and skull base. Design Meta-analysis of the literature and data from the International ACC Study Group. Setting University-affiliated medical center. Participants The study group consisted of 520 patients, 99 of them from the international cohort. The median follow-up period was 60 months (range, 32 to 100 months). Main Outcome Measures Overall survival (OS) and disease-specific survival (DSS). Results The 5-year OS and DSS of the entire cohort were 62% and 67%, respectively. The local recurrence rate was 36.6%, and the regional recurrence rate was 7%. Distant metastasis, most commonly present in the lung, was recorded in 106 patients (29.1%). In the international cohort, positive margins and ACC of the sphenoid or ethmoidal sinuses were significant predictors of outcome (p < 0.001). Perineural invasion and adjuvant treatment (radiotherapy or chemoradiation) were not associated with prognosis. Conclusion Tumor margin status and tumor site are associated with prognosis in ACC of the paranasal sinuses, whereas perineural invasion is not. Adjuvant treatment apparently has no impact on outcome.

Original language	English (US)
Pages (from-to)	118-125
Number of pages	8
Journal	Journal of Neurological Surgery, Part B: Skull Base
Volume	74
Issue number	3
DOIs	https://doi.org/10.1055/s-0033-1347358
State	Published - 2013

Keywords

adenoid cystic carcinoma
meta analysis
paranasal sinuses
skull base
survival

ASJC Scopus subject areas

Clinical Neurology

Access to Document

10.1055/s-0033-1347358

Cite this

Amit, M., Binenbaum, Y., Sharma, K., Naomi, R., Ilana, R., Abib, A., Miles, B., Yang, X., Lei, D., Kristine, B., Christian, G., Thomas, M., Klaus-Dietrich, W., Fliss, D., Eckardt, A. M., Chiara, C., Sesenna, E., Frank, P., Patel, S., & Gil, Z. (2013). Adenoid cystic carcinoma of the nasal cavity and paranasal sinuses: A meta-analysis. Journal of Neurological Surgery, Part B: Skull Base, 74(3), 118-125. https://doi.org/10.1055/s-0033-1347358

Amit, M, Binenbaum, Y, Sharma, K, Naomi, R, Ilana, R, Abib, A, Miles, B, Yang, X, Lei, D, Kristine, B, Christian, G, Thomas, M, Klaus-Dietrich, W, Fliss, D, Eckardt, AM, Chiara, C, Sesenna, E, Frank, P, Patel, S & Gil, Z 2013, 'Adenoid cystic carcinoma of the nasal cavity and paranasal sinuses: A meta-analysis', Journal of Neurological Surgery, Part B: Skull Base, vol. 74, no. 3, pp. 118-125. https://doi.org/10.1055/s-0033-1347358

@article{ef56f8e5a5104427953be2e965d81506,

title = "Adenoid cystic carcinoma of the nasal cavity and paranasal sinuses: A meta-analysis",

abstract = "Objectives To identify independent predictors of outcome in patients with adenoid cystic carcinoma (ACC) of the paranasal sinuses and skull base. Design Meta-analysis of the literature and data from the International ACC Study Group. Setting University-affiliated medical center. Participants The study group consisted of 520 patients, 99 of them from the international cohort. The median follow-up period was 60 months (range, 32 to 100 months). Main Outcome Measures Overall survival (OS) and disease-specific survival (DSS). Results The 5-year OS and DSS of the entire cohort were 62% and 67%, respectively. The local recurrence rate was 36.6%, and the regional recurrence rate was 7%. Distant metastasis, most commonly present in the lung, was recorded in 106 patients (29.1%). In the international cohort, positive margins and ACC of the sphenoid or ethmoidal sinuses were significant predictors of outcome (p < 0.001). Perineural invasion and adjuvant treatment (radiotherapy or chemoradiation) were not associated with prognosis. Conclusion Tumor margin status and tumor site are associated with prognosis in ACC of the paranasal sinuses, whereas perineural invasion is not. Adjuvant treatment apparently has no impact on outcome.",

keywords = "adenoid cystic carcinoma, meta analysis, paranasal sinuses, skull base, survival",

author = "Moran Amit and Yoav Binenbaum and Kanika Sharma and Ramer Naomi and Ramer Ilana and Agbetoba Abib and Brett Miles and Xinjie Yang and Delin Lei and Bjoerndal Kristine and Godballe Christian and M{\"u}cke Thomas and Wolff Klaus-Dietrich and Dan Fliss and Eckardt, {Andr{\'e} M.} and Copelli Chiara and Enrico Sesenna and Palmer Frank and Snehal Patel and Ziv Gil",

year = "2013",

doi = "10.1055/s-0033-1347358",

language = "English (US)",

volume = "74",

pages = "118--125",

journal = "Journal of Neurological Surgery, Part B: Skull Base",

issn = "2193-634X",

publisher = "Thieme Medical Publishers",

number = "3",

}

TY - JOUR

T1 - Adenoid cystic carcinoma of the nasal cavity and paranasal sinuses

T2 - A meta-analysis

AU - Amit, Moran

AU - Binenbaum, Yoav

AU - Sharma, Kanika

AU - Naomi, Ramer

AU - Ilana, Ramer

AU - Abib, Agbetoba

AU - Miles, Brett

AU - Yang, Xinjie

AU - Lei, Delin

AU - Kristine, Bjoerndal

AU - Christian, Godballe

AU - Thomas, Mücke

AU - Klaus-Dietrich, Wolff

AU - Fliss, Dan

AU - Eckardt, André M.

AU - Chiara, Copelli

AU - Sesenna, Enrico

AU - Frank, Palmer

AU - Patel, Snehal

AU - Gil, Ziv

PY - 2013

Y1 - 2013

N2 - Objectives To identify independent predictors of outcome in patients with adenoid cystic carcinoma (ACC) of the paranasal sinuses and skull base. Design Meta-analysis of the literature and data from the International ACC Study Group. Setting University-affiliated medical center. Participants The study group consisted of 520 patients, 99 of them from the international cohort. The median follow-up period was 60 months (range, 32 to 100 months). Main Outcome Measures Overall survival (OS) and disease-specific survival (DSS). Results The 5-year OS and DSS of the entire cohort were 62% and 67%, respectively. The local recurrence rate was 36.6%, and the regional recurrence rate was 7%. Distant metastasis, most commonly present in the lung, was recorded in 106 patients (29.1%). In the international cohort, positive margins and ACC of the sphenoid or ethmoidal sinuses were significant predictors of outcome (p < 0.001). Perineural invasion and adjuvant treatment (radiotherapy or chemoradiation) were not associated with prognosis. Conclusion Tumor margin status and tumor site are associated with prognosis in ACC of the paranasal sinuses, whereas perineural invasion is not. Adjuvant treatment apparently has no impact on outcome.

AB - Objectives To identify independent predictors of outcome in patients with adenoid cystic carcinoma (ACC) of the paranasal sinuses and skull base. Design Meta-analysis of the literature and data from the International ACC Study Group. Setting University-affiliated medical center. Participants The study group consisted of 520 patients, 99 of them from the international cohort. The median follow-up period was 60 months (range, 32 to 100 months). Main Outcome Measures Overall survival (OS) and disease-specific survival (DSS). Results The 5-year OS and DSS of the entire cohort were 62% and 67%, respectively. The local recurrence rate was 36.6%, and the regional recurrence rate was 7%. Distant metastasis, most commonly present in the lung, was recorded in 106 patients (29.1%). In the international cohort, positive margins and ACC of the sphenoid or ethmoidal sinuses were significant predictors of outcome (p < 0.001). Perineural invasion and adjuvant treatment (radiotherapy or chemoradiation) were not associated with prognosis. Conclusion Tumor margin status and tumor site are associated with prognosis in ACC of the paranasal sinuses, whereas perineural invasion is not. Adjuvant treatment apparently has no impact on outcome.

KW - adenoid cystic carcinoma

KW - meta analysis

KW - paranasal sinuses

KW - skull base

KW - survival

UR - http://www.scopus.com/inward/record.url?scp=84878768300&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878768300&partnerID=8YFLogxK

U2 - 10.1055/s-0033-1347358

DO - 10.1055/s-0033-1347358

M3 - Article

AN - SCOPUS:84878768300

SN - 2193-634X

VL - 74

SP - 118

EP - 125

JO - Journal of Neurological Surgery, Part B: Skull Base

JF - Journal of Neurological Surgery, Part B: Skull Base

IS - 3

ER -

Adenoid cystic carcinoma of the nasal cavity and paranasal sinuses: A meta-analysis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this