Addressing the genetic/nongenetic duality in cancer with systems biology

Prakash Kulkarni; H. Steven Wiley; Herbert Levine; Herbert Sauro; Alexander Anderson; Stephen T.C. Wong; Aaron S. Meyer; Puneeth Iyengar; Kevin Corlette; Kristin Swanson; Atish Mohanty; Supriyo Bhattacharya; Amit Patel; Vinay Jain; Ravi Salgia

doi:10.1016/j.trecan.2022.12.004

Addressing the genetic/nongenetic duality in cancer with systems biology

Prakash Kulkarni, H. Steven Wiley, Herbert Levine, Herbert Sauro, Alexander Anderson, Stephen T.C. Wong, Aaron S. Meyer, Puneeth Iyengar, Kevin Corlette, Kristin Swanson, Atish Mohanty, Supriyo Bhattacharya, Amit Patel, Vinay Jain, Ravi Salgia

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The dogma that cancer is a genetic disease is being questioned. Recent findings suggest that genetic/nongenetic duality is necessary for cancer progression. A think tank organized by the Shraman Foundation's Institute for Theoretical Biology compiled key challenges and opportunities that theoreticians, experimentalists, and clinicians can explore from a systems biology perspective to provide a better understanding of the disease as well as help discover new treatment options and therapeutic strategies.

Original language	English (US)
Pages (from-to)	185-187
Number of pages	3
Journal	Trends in Cancer
Volume	9
Issue number	3
DOIs	https://doi.org/10.1016/j.trecan.2022.12.004
State	Published - Mar 2023

ASJC Scopus subject areas

Oncology
Cancer Research

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Medical Oncology

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10.1016/j.trecan.2022.12.004

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title = "Addressing the genetic/nongenetic duality in cancer with systems biology",

abstract = "The dogma that cancer is a genetic disease is being questioned. Recent findings suggest that genetic/nongenetic duality is necessary for cancer progression. A think tank organized by the Shraman Foundation's Institute for Theoretical Biology compiled key challenges and opportunities that theoreticians, experimentalists, and clinicians can explore from a systems biology perspective to provide a better understanding of the disease as well as help discover new treatment options and therapeutic strategies.",

author = "Prakash Kulkarni and Wiley, \{H. Steven\} and Herbert Levine and Herbert Sauro and Alexander Anderson and Wong, \{Stephen T.C.\} and Meyer, \{Aaron S.\} and Puneeth Iyengar and Kevin Corlette and Kristin Swanson and Atish Mohanty and Supriyo Bhattacharya and Amit Patel and Vinay Jain and Ravi Salgia",

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year = "2023",

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doi = "10.1016/j.trecan.2022.12.004",

language = "English (US)",

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AU - Kulkarni, Prakash

AU - Wiley, H. Steven

AU - Levine, Herbert

AU - Sauro, Herbert

AU - Anderson, Alexander

AU - Wong, Stephen T.C.

AU - Meyer, Aaron S.

AU - Iyengar, Puneeth

AU - Corlette, Kevin

AU - Swanson, Kristin

AU - Mohanty, Atish

AU - Bhattacharya, Supriyo

AU - Patel, Amit

AU - Jain, Vinay

AU - Salgia, Ravi

PY - 2023/3

Y1 - 2023/3

N2 - The dogma that cancer is a genetic disease is being questioned. Recent findings suggest that genetic/nongenetic duality is necessary for cancer progression. A think tank organized by the Shraman Foundation's Institute for Theoretical Biology compiled key challenges and opportunities that theoreticians, experimentalists, and clinicians can explore from a systems biology perspective to provide a better understanding of the disease as well as help discover new treatment options and therapeutic strategies.

AB - The dogma that cancer is a genetic disease is being questioned. Recent findings suggest that genetic/nongenetic duality is necessary for cancer progression. A think tank organized by the Shraman Foundation's Institute for Theoretical Biology compiled key challenges and opportunities that theoreticians, experimentalists, and clinicians can explore from a systems biology perspective to provide a better understanding of the disease as well as help discover new treatment options and therapeutic strategies.

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AN - SCOPUS:85146136263

SN - 2405-8033

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EP - 187

JO - Trends in Cancer

JF - Trends in Cancer

IS - 3

ER -

Addressing the genetic/nongenetic duality in cancer with systems biology

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