Addressing the genetic/nongenetic duality in cancer with systems biology

Prakash Kulkarni, H. Steven Wiley, Herbert Levine, Herbert Sauro, Alexander Anderson, Stephen T.C. Wong, Aaron S. Meyer, Puneeth Iyengar, Kevin Corlette, Kristin Swanson, Atish Mohanty, Supriyo Bhattacharya, Amit Patel, Vinay Jain, Ravi Salgia

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The dogma that cancer is a genetic disease is being questioned. Recent findings suggest that genetic/nongenetic duality is necessary for cancer progression. A think tank organized by the Shraman Foundation's Institute for Theoretical Biology compiled key challenges and opportunities that theoreticians, experimentalists, and clinicians can explore from a systems biology perspective to provide a better understanding of the disease as well as help discover new treatment options and therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)185-187
Number of pages3
JournalTrends in Cancer
Issue number3
StatePublished - Mar 2023

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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