Adaptive features of innate immune cells and their relevance to graft rejection

Research output: Contribution to journalReview article

Guangchuan Wang, Gangcheng Kong, Xian Chang Li

Purpose of reviewAllograft rejection involves both innate and adaptive immune cells, and the adaptive immune cells have dominated transplant studies for decades. Recent studies have identified surprising new features for the innate immune cells, including memory recall responses, which may have significant implications in further improvement of transplant outcomes.Recent findingsTransplant survival is excellent in the short-term, but the long-term graft outcomes are not so, and most grafts are continuously lost to chronic rejection in the clinic. In both animal models and clinical settings, graft loss to chronic rejection is often dominated by innate immune cells, especially macrophages and natural killer (NK) cells in the grafts. Recent studies suggest that innate immune cells can acquire features of adaptive cells in that they either directly sense allogeneic nonself or become 'trained' in the allogeneic milieu, where they show features of memory recall responses. In certain models, targeting the adaptive features of such innate immune cells can promote long-term allograft survival. These findings may open new therapeutic opportunities in promoting transplant survival in the clinic.SummaryThe discovery of donor specificity and memory recall responses of certain innate immune cells, which are prominently featured in chronic allograft rejection, may open novel therapeutic opportunities in transplantation, as well as in treatment of cancers and autoimmune diseases.

Original languageEnglish (US)
Pages (from-to)664-669
Number of pages6
JournalCurrent opinion in organ transplantation
Volume24
Issue number6
DOIs
StatePublished - Dec 1 2019

PMID: 31577598

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Adaptive features of innate immune cells and their relevance to graft rejection. / Wang, Guangchuan; Kong, Gangcheng; Li, Xian Chang.

In: Current opinion in organ transplantation, Vol. 24, No. 6, 01.12.2019, p. 664-669.

Research output: Contribution to journalReview article

Harvard

Wang, G, Kong, G & Li, XC 2019, 'Adaptive features of innate immune cells and their relevance to graft rejection' Current opinion in organ transplantation, vol. 24, no. 6, pp. 664-669. https://doi.org/10.1097/MOT.0000000000000707

APA

Wang, G., Kong, G., & Li, X. C. (2019). Adaptive features of innate immune cells and their relevance to graft rejection. Current opinion in organ transplantation, 24(6), 664-669. https://doi.org/10.1097/MOT.0000000000000707

Vancouver

Wang G, Kong G, Li XC. Adaptive features of innate immune cells and their relevance to graft rejection. Current opinion in organ transplantation. 2019 Dec 1;24(6):664-669. https://doi.org/10.1097/MOT.0000000000000707

Author

Wang, Guangchuan ; Kong, Gangcheng ; Li, Xian Chang. / Adaptive features of innate immune cells and their relevance to graft rejection. In: Current opinion in organ transplantation. 2019 ; Vol. 24, No. 6. pp. 664-669.

BibTeX

@article{ae57b8c3937347c0949b50f7ec183a1b,
title = "Adaptive features of innate immune cells and their relevance to graft rejection",
abstract = "Purpose of reviewAllograft rejection involves both innate and adaptive immune cells, and the adaptive immune cells have dominated transplant studies for decades. Recent studies have identified surprising new features for the innate immune cells, including memory recall responses, which may have significant implications in further improvement of transplant outcomes.Recent findingsTransplant survival is excellent in the short-term, but the long-term graft outcomes are not so, and most grafts are continuously lost to chronic rejection in the clinic. In both animal models and clinical settings, graft loss to chronic rejection is often dominated by innate immune cells, especially macrophages and natural killer (NK) cells in the grafts. Recent studies suggest that innate immune cells can acquire features of adaptive cells in that they either directly sense allogeneic nonself or become 'trained' in the allogeneic milieu, where they show features of memory recall responses. In certain models, targeting the adaptive features of such innate immune cells can promote long-term allograft survival. These findings may open new therapeutic opportunities in promoting transplant survival in the clinic.SummaryThe discovery of donor specificity and memory recall responses of certain innate immune cells, which are prominently featured in chronic allograft rejection, may open novel therapeutic opportunities in transplantation, as well as in treatment of cancers and autoimmune diseases.",
keywords = "innate immune cells, macrophages, memory, natural killer cells, transplant rejection",
author = "Guangchuan Wang and Gangcheng Kong and Li, {Xian Chang}",
year = "2019",
month = "12",
day = "1",
doi = "10.1097/MOT.0000000000000707",
language = "English (US)",
volume = "24",
pages = "664--669",
journal = "Current Opinion in Organ Transplantation",
issn = "1087-2418",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

RIS

TY - JOUR

T1 - Adaptive features of innate immune cells and their relevance to graft rejection

AU - Wang, Guangchuan

AU - Kong, Gangcheng

AU - Li, Xian Chang

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Purpose of reviewAllograft rejection involves both innate and adaptive immune cells, and the adaptive immune cells have dominated transplant studies for decades. Recent studies have identified surprising new features for the innate immune cells, including memory recall responses, which may have significant implications in further improvement of transplant outcomes.Recent findingsTransplant survival is excellent in the short-term, but the long-term graft outcomes are not so, and most grafts are continuously lost to chronic rejection in the clinic. In both animal models and clinical settings, graft loss to chronic rejection is often dominated by innate immune cells, especially macrophages and natural killer (NK) cells in the grafts. Recent studies suggest that innate immune cells can acquire features of adaptive cells in that they either directly sense allogeneic nonself or become 'trained' in the allogeneic milieu, where they show features of memory recall responses. In certain models, targeting the adaptive features of such innate immune cells can promote long-term allograft survival. These findings may open new therapeutic opportunities in promoting transplant survival in the clinic.SummaryThe discovery of donor specificity and memory recall responses of certain innate immune cells, which are prominently featured in chronic allograft rejection, may open novel therapeutic opportunities in transplantation, as well as in treatment of cancers and autoimmune diseases.

AB - Purpose of reviewAllograft rejection involves both innate and adaptive immune cells, and the adaptive immune cells have dominated transplant studies for decades. Recent studies have identified surprising new features for the innate immune cells, including memory recall responses, which may have significant implications in further improvement of transplant outcomes.Recent findingsTransplant survival is excellent in the short-term, but the long-term graft outcomes are not so, and most grafts are continuously lost to chronic rejection in the clinic. In both animal models and clinical settings, graft loss to chronic rejection is often dominated by innate immune cells, especially macrophages and natural killer (NK) cells in the grafts. Recent studies suggest that innate immune cells can acquire features of adaptive cells in that they either directly sense allogeneic nonself or become 'trained' in the allogeneic milieu, where they show features of memory recall responses. In certain models, targeting the adaptive features of such innate immune cells can promote long-term allograft survival. These findings may open new therapeutic opportunities in promoting transplant survival in the clinic.SummaryThe discovery of donor specificity and memory recall responses of certain innate immune cells, which are prominently featured in chronic allograft rejection, may open novel therapeutic opportunities in transplantation, as well as in treatment of cancers and autoimmune diseases.

KW - innate immune cells

KW - macrophages

KW - memory

KW - natural killer cells

KW - transplant rejection

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UR - http://www.scopus.com/inward/citedby.url?scp=85073423750&partnerID=8YFLogxK

U2 - 10.1097/MOT.0000000000000707

DO - 10.1097/MOT.0000000000000707

M3 - Review article

VL - 24

SP - 664

EP - 669

JO - Current Opinion in Organ Transplantation

T2 - Current Opinion in Organ Transplantation

JF - Current Opinion in Organ Transplantation

SN - 1087-2418

IS - 6

ER -

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ID: 54649957